Breast cancer biomarkers: proteomic discovery and translation to clinically relevant assays

Expert Review of Proteomics
Liping Chung, Robert C Baxter

Abstract

Although the molecular classification and prognostic assessment of breast tumors based on gene expression profiling is well established, a number of proteomic studies that propose potential breast cancer biomarkers has not yet led to any new diagnostic, prognostic or predictive test in wide clinical use. This review examines the current status of breast cancer biomarkers, discusses sample types (including plasma, tumor tissue, nipple aspirate and ductal lavage, as well as cell culture models) and different electrophoretic and mass spectrometry methods that have been widely used for the discovery of proteomic biomarkers in breast cancer, and also considers several approaches to biomarker validation. The pathway leading from the initial proteomic discovery and validation process to translation into a clinically useful test is also discussed.

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Citations

Jul 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maria KabbageKarim Chahed
May 20, 2014·Expert Review of Proteomics·Pavel GromovIrina Gromova
Feb 27, 2015·Expert Review of Proteomics·Petra HudlerRadovan Komel
Oct 4, 2014·Journal of Hematology & Oncology·Alan D SmithTimothy A Yap
Aug 20, 2015·Molecular Oncology·Tommaso De MarchiArzu Umar
Mar 13, 2014·Proteomics. Clinical Applications·Mikkel G Terp, Henrik J Ditzel
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Nov 30, 2014·Molecular & Cellular Proteomics : MCP·Bobbie-Jo M Webb-RobertsonKatrina M Waters
Feb 16, 2018·Breast Cancer Research : BCR·Sanna ByströmMarike Gabrielson

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