Breast cancer during pregnancy: a retrospective study on obstetrical problems and survival

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Marialuisa Framarino-Dei-MalatestaPaolo Sammartino

Abstract

Breast cancer is one of the most common cancers occurring in pregnancy. Data on survival of these patients and their obstetrical complications are still limited. We conducted a case-control, retrospective study to evaluate the overall survival (OS) of 22 patients with breast cancer in pregnancy (BCP) and 45 non-pregnant women with breast cancer (BC) matched for age, stage and hormonal status. Survival of BCP and BC patients using Kaplan-Meier analysis was similar (86.4% in cases and 80% in controls p=0.392) and BCP patients had survival consistent with the stage of the disease, providing that the treatment had been in agreement with the recommended protocols. The overall incidence of premature delivery was 54.6% and complications were observed in three newborns out of 23 (13%). Preterm labor induction without any obstetrical indication following woman's request to continue chemotherapy outside pregnancy can be reduced by explaining the risks of early delivery and the lack of effects of many chemotherapeutic regimens on the fetus.

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Citations

May 29, 2015·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Oihana PascualMaria-Reyes Abad
Jun 19, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Natalia R Gomez-HidalgoJuan De Leon-Luis
Mar 25, 2017·European Journal of Cancer Care·K HammarbergJ Fisher
Sep 30, 2016·Breast Cancer Research and Treatment·Emily K Hartman, Guy D Eslick
Aug 12, 2020·BMC Cancer·Chunchun ShaoHongying Jia
May 6, 2019·Expert Review of Hematology·Anna Gurevich-Shapiro, Irit Avivi

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