Breast cancer epigenetics: normal human mammary epithelial cells as a model system.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Rebecca A Hinshelwood, Susan J Clark

Abstract

DNA hypermethylation and histone modifications are two critical players involved in epigenetic regulation and together play an important role in silencing tumor-suppressor genes in all cancers, including breast cancer. One of the major challenges facing breast cancer researchers is the problem of how to identify critical genes that are epigenetically silenced early in cancer initiation as these genes provide potential early diagnostic and/or therapeutic targets for breast cancer management. This review will focus on compelling evidence that normal Human Mammary Epithelial Cells (HMECs) that escape senescence in culture mimic genetic and epigenetic events occurring in early breast cancer, and provide a valuable system to delineate the early steps in epigenetic deregulation that often occur during transition of a normal breast cell to a premalignant cell. In particular, this model system has been used to investigate the relationship between gene silencing, DNA methylation, histone modifications, and polycomb association that may occur early in oncogenic transformation.

References

May 11, 1992·Nucleic Acids Research·R W YenS B Baylin
Jan 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·P L Molloy, F Watt
Mar 23, 1990·Cell·J Tazi, A Bird
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A JonesS J Tapscott
Jan 1, 1990·Advances in Cancer Research·P A Jones, J D Buckley
Aug 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M Hosobuchi, M R Stampfer
Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M R Stampfer, J C Bartley
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S L HammondM R Stampfer
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Antequera, A Bird
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Apr 1, 1995·Nature Genetics·L HoskingA Jeffreys
Apr 1, 1995·Nature Genetics·S D MerajverT S Frank
Jan 1, 1994·Human Molecular Genetics·P W Laird, R Jaenisch
Oct 7, 1994·Science·P A FutrealY Miki
May 1, 1994·Clinical & Experimental Metastasis·E W ThompsonR B Dickson
Feb 1, 1996·Seminars in Cancer Biology·C F Xu, E Solomon
Apr 7, 1998·Molecular and Cellular Biology·S A FosterD A Galloway
Mar 24, 1999·Trends in Genetics : TIG·P A Jones
Oct 12, 1999·Breast Cancer Research and Treatment·D E LauxT H Huang
Jan 19, 2000·Nature·B D Strahl, C D Allis
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·F E DomannB W Futscher
Mar 24, 2000·Trends in Genetics : TIG·S B Baylin, J G Herman
Apr 6, 2000·Journal of the National Cancer Institute·M EstellerJ G Herman
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·A T FergusonS Sukumar
May 18, 2000·Journal of the National Cancer Institute·M WidschwendterC Marth
Apr 3, 2001·Annals of Internal Medicine·V SantiniJ P Issa
May 3, 2001·Journal of the National Cancer Institute·D G BurbeeJ D Minna
Nov 13, 2001·Oncogene·Y Y XiangJ Filmus

❮ Previous
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Citations

Nov 22, 2011·Breast Cancer Research and Treatment·Natalie E SimpsonIgor P Pogribny
Apr 24, 2012·DNA and Cell Biology·Lauren P Blair, Qin Yan
Jun 21, 2012·Carcinogenesis·Kwan Yeung WongChor Sang Chim
Jul 9, 2010·Cold Spring Harbor Perspectives in Biology·Tim H-M Huang, Manel Esteller
Nov 16, 2012·BMC Genomics·Anita GrigoriadisAndrew Tutt
Oct 6, 2010·Breast Cancer Research : BCR·Naiara G BediagaMarian M de Pancorbo
Nov 22, 2012·Breast Cancer Research : BCR·Warwick J Locke, Susan J Clark
Jun 17, 2011·Future Oncology·Marco A Velasco-VelázquezRichard G Pestell
Nov 20, 2014·Breast Cancer Research and Treatment·Gianluca SeveriLaura Baglietto
Mar 28, 2009·Cellular and Molecular Life Sciences : CMLS·Igor P Pogribny, Frederick A Beland
Jun 4, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Geir MjøenHallvard Holdaas
May 23, 2015·Molecular Medicine Reports·Du-Guan Fu
Mar 10, 2010·Molecular and Cellular Endocrinology·Kevin C KnowerColin D Clyne
Apr 15, 2011·Cancer Science·Naoko HattoriToshikazu Ushijima
Apr 29, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Annina Nickel, Sonja C Stadler
Jul 16, 2010·Molecular Oncology·Jovana JovanovicVessela Kristensen
Jan 15, 2011·Molecular Cancer·Cinzia AllegrucciAndrew D Johnson
Aug 26, 2014·In Vitro Cellular & Developmental Biology. Animal·Pranapda AumsuwanAsok K Dasmahapatra
Oct 31, 2014·Oncology Nursing Forum·Nabila S Rattani, Theresa Swift-Scanlan
Aug 5, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Armina-Lyn M FrederickZhenhua Liu
Mar 20, 2018·Pathology Oncology Research : POR· PuneetGopeshwar Narayan
Nov 1, 2018·Advanced Biosystems·Rachel L MintzKam W Leong
Jan 8, 2021·PLoS Genetics·Bettina J LehmanBeverly M Emerson
Sep 7, 2021·Frontiers in Cell and Developmental Biology·Liang Gao, Fangfang Zhou

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