Breast cancer genetics and cancer control. Tumor association.

Archives of Surgery
H T LynchP Lynch

Abstract

Verified breast cancer was present in a father, his mother, and his daughter. His sone had a brain tumor (by history) and his grandson, (ehs sone of the affected daughter), had a histologically verified rhabdomyosarcoma. This familial aggregation of cancers (except for leukemia, which is absent) is consistent with a newly described familial breast cancer syndrome. A single pleiotropic, dominantly transmitted gene, possibly interacting with carcinogenic factors, such as an oncogenic virus, may be the cause. A cancer-control potential exists for tumor associations such as those exhibited in this kindred, as well as for other cancer genetic syndromes where careful consideration is given to all histologic varieties of cancer.

Citations

Oct 1, 1982·Journal of Medical Genetics·A D PearsonD F Roberts
Oct 1, 1981·American Journal of Public Health·H T Lynch, M A Rahim
Jul 1, 1988·Breast Cancer Research and Treatment·H T LynchJ Lynch
Sep 1, 1984·Cancer Genetics and Cytogenetics·H T LynchB S Danes
Jan 1, 1987·Seminars in Surgical Oncology·G D LukF M Giardiello
Apr 1, 1977·Cancer·H T LynchR E Harris
Jan 1, 1989·World Journal of Surgery·M MooreD G Harnden

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