Breast cancer genetics: what we know and what we need

Nature Medicine
K L NathansonK N Nathanson

Abstract

Breast cancer results from genetic and environmental factors leading to the accumulation of mutations in essential genes. Genetic predisposition may have a strong, almost singular effect, as with BRCA1 and BRCA2, or may represent the cumulative effects of multiple low-penetrance susceptibility alleles. Here we review high- and low-penetrance breast-cancer-susceptibility alleles and discuss ongoing efforts to identify additional susceptibility genes. Ultimately these discoveries will lead to individualized breast cancer risk assessment and a reduction in breast cancer incidence.

References

Dec 26, 1991·The New England Journal of Medicine·M SwiftC L Chase
May 21, 1987·The New England Journal of Medicine·M SwiftC L Chase
Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Nov 1, 1993·Human Molecular Genetics·J M LobaccaroC Sultan
Aug 19, 1993·The New England Journal of Medicine·T G KrontirisN Risch
Mar 1, 1996·Nature Genetics·S V TavtigianD E Goldgar
May 25, 1996·Lancet·J P StruewingJ D Boice
Aug 22, 1996·Nature·M S Chapman, I M Verma
Jan 24, 1997·Cell·R ScullyD M Livingston
Mar 1, 1997·Nature Genetics·M G FitzGeraldD A Haber
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
May 15, 1997·The New England Journal of Medicine·F J CouchB L Weber
Jun 20, 1998·Annals of Internal Medicine·L A BoardmanL C Hartmann
Jul 14, 1998·Molecular Cell·K J PatelA R Venkitaraman
Dec 5, 1998·Journal of the National Cancer Institute·E B ClausG Parmigiani
Mar 31, 1999·British Journal of Cancer·H M InskipC F Arlett
Apr 17, 1999·American Journal of Human Genetics·T R RebbeckM Brown
Jun 8, 1999·Journal of the National Cancer Institute·J PetoM R Stratton
Aug 5, 1999·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Linkage Consortium
Mar 21, 2000·American Journal of Human Genetics·A BroeksL J van 't Veer
Apr 28, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A EisenB L Weber
Aug 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·T KainuH Nevanlinna
Dec 2, 2000·Nature·R Scully, D M Livingston
Dec 6, 2000·British Journal of Cancer·K LaakeA L Børresen-Dale
Feb 24, 2001·The New England Journal of Medicine·I HedenfalkG Sauter
Jul 11, 2001·Novartis Foundation Symposium·K NasmythF Uhlmann

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Citations

Mar 7, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Angela Burk-HerrickMark S Springer
Dec 7, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Claude Szpirer, Josiane Szpirer
Oct 25, 2006·Breast Cancer Research and Treatment·Jana ProkopcovaPetr Pohlreich
Apr 24, 2013·Breast Cancer Research and Treatment·Ziang YangBiyun Wang
Mar 3, 2007·Familial Cancer·Anna P SokolenkoEvgeny N Imyanitov
Jan 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yulan YanXue Qin
Jun 3, 2004·Biochimica Et Biophysica Acta·Manuela Santarosa, Alan Ashworth
Mar 18, 2004·Breast Cancer Research and Treatment·Yvonne Marie Coyle
Dec 19, 2008·European Journal of Human Genetics : EJHG·Tim RippergerBrigitte Schlegelberger
Nov 21, 2002·Nature·Luca PellegriniAshok R Venkitaraman
May 23, 2007·Nature Structural & Molecular Biology·Owen Richard Davies, Luca Pellegrini
May 11, 2004·Nature Structural & Molecular Biology·Julie A ClappertonStephen J Smerdon
May 11, 2004·Nature Structural & Molecular Biology·R Scott WilliamsJ N Mark Glover
Jan 26, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Jesús Pérez-LosadaJian-Hua Mao
Nov 8, 2002·The New England Journal of Medicine·Alan E Guttmacher, Francis S Collins
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·El Mustapha BahassiPeter J Stambrook
Sep 18, 2001·Journal of Women's Health & Gender-based Medicine
May 21, 2010·Journal of the National Cancer Institute·Wei ZhengWei Lu
Aug 13, 2013·Nucleic Acids Research·Shyamal SubramanyamM Ashley Spies
Mar 5, 2011·Annals of Surgery·Tari A KingMonica Morrow
Dec 19, 2003·Genes & Development·Mikhail LomonosovAshok R Venkitaraman
Aug 1, 2007·Molecular and Cellular Biology·Easwari Kumaraswamy, Ramin Shiekhattar
Oct 29, 2008·Annual Review of Pathology·Ashok R Venkitaraman
Aug 4, 2006·Cancer Research·Sam Thiagalingam
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer T LoudMark H Greene
Mar 29, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Celine M VachonIsabel dos-Santos-Silva
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Montserrat Garcia-Closas, Stephen Chanock

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