Breast cancer markers

Cancer Letters
Vincenzo Giancotti

Abstract

This review illustrates the relationships linking the ER and the ErbB family of receptor tyrosine kinases and their kinase pathways in breast cancer. The central role of the ER in activating tumour growth linked gene transcription as well as the cooperating nuclear co-factors very likely implicated in breast cancer tumourigenesis is discussed. The action of ErbB family members has been located upstream of the kinase pathways that begin at plasma membrane and end at the nucleus after complex interconnections with many factors, such as AP-1. The important role of MAPKs and PKB/Akt in cell survival and tumour proliferation is highlighted. Also other factors are discussed such as Fra-1 (a member of the AP-1 complex), E-cadherin (a tumour suppressor), and BRCA1 (another factor involved in tumour growth inhibition). Lactoferrin protein (characteristic of healthy tissues) and resistance proteins have also been briefly discussed.

Citations

Oct 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Masoumeh Tavakoli-YarakiMajid Sirati-Sabet
Dec 19, 2008·Critical Reviews in Food Science and Nutrition·Lígia RodriguesHelena Lindmark Månsson
May 26, 2009·Clinical & Experimental Metastasis·Sylvia E Le DévédecBob van de Water
Apr 26, 2008·Biochemical and Biophysical Research Communications·Pavan AdiseshaiahSekhar P Reddy
Dec 25, 2010·Journal of Dairy Science·D C DuarteL R Rodrigues
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jilong GuoBin Zhang
Jan 29, 2019·Frontiers in Immunology·Alexandre Thibault Jacques MariaPhilippe Guilpain
Dec 22, 2016·Menopause : the Journal of the North American Menopause Society·Mirette HannaCaroline Diorio
Jan 28, 2014·Molecular Biology Reports·Fulya DoğanerCengiz Bal

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