Breast Cancer: Metastasis, Molecular Subtypes, and Overweight and Obesity in Veracruz, Mexico

Clinical Breast Cancer
Carlos Adrián Alarcón RojasGuillermo Contreras-Alarcón

Abstract

We assessed the association between overweight, obesity, and morbid obesity with the incidence of the most aggressive breast cancer subtypes in women. A cross-sectional study was performed. We conducted a record review to identify the following aspects: body mass index, sociodemographic features, tumor characteristics, and reproductive and molecular aspects. Descriptive statistics and univariate analysis were performed to identify the association between the molecular subtypes and the study variables. In addition, we used multivariate analysis to identify the association between obesity and the presence of metastatic lymph nodes. We included 1446 women with an average age of 52.5 ± 12.1 years. Of the 1446 patients, 47% were premenopausal and 75% were overweight. Univariate analysis indicated a statistically significant association between obesity and advanced disease stage, as well as nulliparity and multiparity. Similar results were found for women with morbid obesity. Model 1 of the multivariate analysis showed an association between the presence of metastatic lymph nodes and obesity (odds ratio [OR], 1.6; P = .008) and histologic grade 2 or 3 (OR, 2.4; P = .003). Using model 2, an association was identified between an advanc...Continue Reading

Citations

Nov 19, 2020·Nature Communications·Lintao SongSheng-Cai Lin
Mar 30, 2021·Complementary Therapies in Clinical Practice·María T Alvarez-BañuelosEstefanía Llanillo-Luján
Aug 6, 2021·Frontiers in Oncology·Chongru ZhaoYiping Wu
Sep 25, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ines BaroneSebastiano Andò
Sep 7, 2019·Seminars in Cancer Biology·Ines BaroneStefania Catalano

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