Breast cancer models to study the expression of estrogen receptors with small animal PET imaging

Nuclear Medicine and Biology
Antonio AliagaFrançois Bénard

Abstract

Different animal models of estrogen positive tumors (ER+) were evaluated for their suitability to follow tumor response after various treatment protocols, using small animal positron emission tomography (PET). ER+ human breast cancer cell lines MCF-7 and T-47D, using MDA-MB-231 as ER-; control, and murine mammary ductal carcinomas MC4-L2, MC4-L3, and MC7-L1, were compared for their in vivo growth rate and retention of ER+ status. Tumor metabolic activity was estimated from the relative uptake (% injected dose/g) of [18F]fluorodeoxyglucose (FDG) uptake, whereas ER content was determined from 16alpha-[18F]fluoroestradiol (FES) retention. F-18 activity values were obtained by small animal PET imaging and confirmed by tissue sampling and radioactivity counting. Reliable uptake measurements could be obtained for tumors of 200 microl or over. The human cell lines grew at a slower rate in vivo and failed to accumulate FES; in contrast, the Balb/c MC7-L1 and MC4-L2 grew well and showed good uptake of both FDG and FES. Chemotherapy and hormone therapy delayed the growth of MC7-L1 and MC4-L2 tumors, confirming their suitability as an ER+ model for therapeutic interventions. MC4-L3 tumors also showed promising results but required the pre...Continue Reading

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Jul 13, 2004·Nuclear Medicine and Biology·Antonio AliagaFrancois Bénard

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Citations

Oct 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Nobukazu TakahashiE Edmund Kim
Dec 17, 2009·Breast Cancer Research and Treatment·Rocío SoldatiClaudia Lanari
Sep 1, 2011·Annals of Nuclear Medicine·Jun Toyohara, Kiichi Ishiwata
May 5, 2009·Cancer Biotherapy & Radiopharmaceuticals·Valentina AmbrosiniDomenico Rubello
Mar 6, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Antonio AliagaFrançois Bénard
Apr 27, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Michel PaquetteRoger Lecomte
Jul 10, 2010·Journal of Biomedical Optics·He N XuLin Z Li
Jun 7, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Amy M FowlerMichael J Welch
Oct 16, 2015·Nuclear Medicine and Biology·Xiaotian XiaXiaoli Lan
Oct 9, 2007·Seminars in Nuclear Medicine·Lavanya SundararajanDavid A Mankoff
Mar 15, 2005·Seminars in Nuclear Medicine·William B Eubank, David A Mankoff
Nov 15, 2011·Nuclear Medicine and Biology·Michel PaquetteFrançois Bénard
Jul 13, 2004·Nuclear Medicine and Biology·Antonio AliagaFrancois Bénard
Aug 12, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Michel PaquetteÉric E Turcotte

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