Breast cancer mortality in synchronous bilateral breast cancer patients

British Journal of Cancer
Mathias Kvist MejdahlNiels Kroman

Abstract

Evidence suggests that patients with synchronous bilateral breast cancer (SBBC), diagnosed within 4 months, have an inferior prognosis compared to unilateral breast cancer (UBC) patients. Using data from nationwide Danish clinical databases, this cohort study investigated whether the inferior prognosis could be explained by SBBC patients having a more aggressive disease, or whether the prognosis could be explained by the fact that they have two simultaneous cancers. Patients were diagnosed from 1999-2015. The main outcome was excess mortality, subtracting background population mortality from observed mortality. Differences between SBBC and UBC patients were evaluated by rate ratios (RR) and estimated by Poisson regression. In total, 1214 SBBC and 59 177 UBC patients were included. SBBC patients had a significantly higher excess mortality than UBC patients after adjustment for age and period (RR = 1.73; 95% CI:1.44-2.08; p < 0.01) and after adjusting for characteristics of the worst tumour as traditionally done (RR = 1.31; 95% CI:1.08-1.57; p = 0.01). However, adjusting for characteristics of both tumours, using a more advanced competing risks model, no difference was observed (RR = 1.01; 95% CI:0.83-1.22; p = 0.93). Our study d...Continue Reading

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Citations

Jul 6, 2020·International Journal of Cancer. Journal International Du Cancer·Joost R C LameijerLucien E M Duijm
Dec 15, 2019·Expert Review of Molecular Diagnostics·Evgeny N Imyanitov, Ekatherina Sh Kuligina
Mar 29, 2021·The Breast : Official Journal of the European Society of Mastology·Shuning DingKunwei Shen
Jul 28, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Shirley LiuJohn A Ronald

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