Breast cancer outcomes by steroid hormone receptor status assessed visually and by computer image analysis

Histopathology
Zahra M A MohammedJames J Going

Abstract

To compare the assessment of steroid hormone receptor immunohistochemistry by eye and by computer-aided image analysis, and to examine their relationships with survival in breast cancer. Allred scores and weighted histoscores for oestrogen receptor (ER) and progesterone receptor (PR) immunohistochemistry were determined by eye (visual histoscore) for 459 primary invasive ductal breast carcinomas in triplicate tissue microarrays. Histoscores were also determined by computerized image analysis (automated histoscore). ER and PR status determined by these different methods were compared with each other and in their ability to predict survival over at least 142 months of follow-up. Allred and visual histoscore were highly associated for ER and PR (both P < 0.001). By univariate analysis, Allred score and visual histoscore for ER and PR were highly associated with recurrence-free and cancer-specific survival (both P < 0.001) in patients with invasive ductal breast cancer overall, in those who received tamoxifen, and in those with recurrence on tamoxifen. Visual and automated histoscores were in excellent agreement for ER and PR (both P < 0.001), and were equally effective in predicting recurrence and survival for patients with invasi...Continue Reading

References

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Citations

Dec 24, 2014·Journal of Pathology Informatics·Jeffrey L Fine
Oct 25, 2013·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Arthur HattelBhushan Jayarao
Dec 23, 2016·International Journal of Cancer. Journal International Du Cancer·Lindsay BennettJoanne Edwards
Mar 2, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nina Lykkegaard AndersenMogens Vyberg
Jan 18, 2018·Cell Death & Disease·Kirsteen J CampbellKaren Blyth
Jul 19, 2019·Arkhiv patologii·P V NikitinS V Shugay

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