Breast cancer-related lymphedema after axillary lymph node dissection: does early postoperative prediction model work?

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
A SoranRonald Johnson

Abstract

Early detection and timely intervention demonstrate the greatest promise of reducing the incidence of late-stage lymphedema in breast cancer patients undergoing axillary lymph node dissection (ALND). A nomogram was developed for predicting the risk of lymphedema (LE) in patients with ALND. This study's aim was to test the early postoperative prediction model for the diagnosis of clinical and subclinical LE after ALND. Patients requiring ALND were identified preoperatively through our LE program database. Measurements using metered tape with bioimpedance spectroscopy (L-Dex® U400) were obtained preoperatively (n = 180) and at 3-6-month intervals postoperatively. The 5-year probability of LE after ALND was calculated using the Cleveland Clinic Risk Calculator. The discrimination of the nomogram was assessed by calculating the area under (AUC) the receiver operating characteristic curve. LE was present in 36.1 % (n = 65) of 180 patients with ALND. Of these 65 patients, 22 (12.2 %) had clinical LE and 43 (23.9 %) had subclinical LE. Statistical analyses showed significant differences in BMI and receipt of radiotherapy between patients with and without LE (p = 0.03 and p = 0.01, respectively). AUC was 0.601, 0.614, and 0.600 for the...Continue Reading

References

Jul 1, 1986·The British Journal of Surgery·M W KissinG Westbury
Jan 1, 1987·International Journal of Radiation Oncology, Biology, Physics·G DeloucheJ M Kurtz
Aug 11, 1998·European Journal of Cancer Care·J Smith
Jun 8, 2000·The Australian and New Zealand Journal of Surgery·T L Edwards
Jun 24, 2000·Annals of the New York Academy of Sciences·B H CornishC Hirst
Apr 22, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Zbigniew KopanskiTomasz Kosciuk
Apr 12, 2005·QJM : Monthly Journal of the Association of Physicians·B ClarkW Harlow
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean Lette
Mar 3, 2007·Patient Education and Counseling·Hiba A BaniMayada R Bani
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·José Luiz B BevilacquaKimberly J Van Zee
May 17, 2008·Journal of Clinical Nursing·Jin Hee ParkHae Soo Chung
Jul 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra C HayesBeth Newman
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah A McLaughlinKimberly J Van Zee
Jan 17, 2009·CA: a Cancer Journal for Clinicians·Brian D LawendaPeter A S Johnstone
Nov 3, 2009·Photomedicine and Laser Surgery·Rufina W L Lau, Gladys L Y Cheing
Dec 8, 2009·Journal of Cancer Survivorship : Research and Practice·Gulgun TahanAtilla Soran
Dec 4, 2010·American Journal of Clinical Oncology·Atilla SoranJohn Wilson
Jun 22, 2011·Lymphatic Research and Biology·Richelle GawBruce Cornish
Aug 2, 2011·Journal of the American College of Surgeons·Yeliz CemalBabak J Mehrara
Sep 29, 2011·International Journal of Radiation Oncology, Biology, Physics·Chirag Shah, Frank A Vicini
Mar 8, 2012·Annals of Surgical Oncology·José Luiz B BevilacquaAnke Bergmann
Dec 26, 2012·Journal of the American College of Surgeons·Sarah A McLaughlinJustin Nguyen
Feb 5, 2013·Seminars in Oncology Nursing·Sheila H Ridner
Feb 26, 2013·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Robin J BellSusan R Davis
Nov 15, 2013·Radiation Oncology·Wilfried BudachChristiane Matuschek
Feb 7, 2014·Breast Cancer Research and Treatment·Cynthia L MillerAlphonse G Taghian
Nov 21, 2014·Lymphatic Research and Biology·Mi-Joung LeeSharon Kilbreath

❮ Previous
Next ❯

Citations

Aug 24, 2017·Breast Cancer Research and Treatment·David I KaufmanMarisa Rizzi
Aug 18, 2018·American Journal of Physical Medicine & Rehabilitation·Andrea L ChevilleKathryn J Ruddy
Oct 6, 2018·Physical Therapy·Bolette S RafnKristin L Campbell
May 16, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Michael E J StouthandelTom Van Hoof
Sep 20, 2019·Lymphatic Research and Biology·Paula M C DonahueManus J Donahue
Apr 10, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yuka AoishiYoshiharu Nishimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.