Breast cancer resistance protein (BCRP)-containing circulating microvesicles contribute to chemoresistance in breast cancer

Oncology Letters
Yun ChenXin Ma

Abstract

At present, one of the major problems of cancer therapy is drug resistance. Breast cancer resistance protein (BCRP), a marker of the multidrug-resistant phenotype, affects drug absorption, distribution, metabolism, and excretion in normal tissues. Meanwhile, extracellular vesicles (EVs) have attracted increasing attention as a medium of cell-to-cell communication. However, the association between BCRP and circulating EVs remains unclear. The present study demonstrated that patients who did not respond or had progressive/stable disease following chemotherapy had markedly higher BCRP levels compared to those that did not receive chemotherapy. Moreover, BCRP was upregulated at the mRNA and protein levels in tumor-derived circulating EVs from patients with a poor response to chemotherapy. Interestingly, the results also demonstrated that BCRP was co-expressed with MUC1, which is frequently expressed in breast cancer and is exported via EVs, and both BCRP and MUC1 were up-regulated after chemotherapy. In conclusion, the present study indicates that tumor-derived circulating EVs that carry BCRP may serve as a predictive biomarker of the response to chemotherapy for breast cancer. In addition, the results provide a window for individu...Continue Reading

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Citations

Jan 16, 2020·Cells·Ines StevicFranz Lennard Ricklefs
Sep 11, 2020·International Journal of Molecular Sciences·Gaetano PezzicoliFrancesco Mannavola
Jun 20, 2017·Oncology Reports·Wei GuoJie He
Sep 13, 2020·Cancers·Mariantonia LogozziStefano Fais
Dec 23, 2020·Journal of Mammary Gland Biology and Neoplasia·Fanny A Pelissier VatterHaiying Zhang
Oct 5, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yehuda G AssarafM Helena Vasconcelos
Jan 16, 2020·Cytokine & Growth Factor Reviews·Chiara CiardielloAlfredo Budillon
Dec 8, 2020·Drug Discovery Today·Róisín Daly, Lorraine O'Driscoll
Mar 6, 2021·Proteomics·Vivian Weiwen XueWilliam Chi Shing Cho
Jun 5, 2021·Advanced Drug Delivery Reviews·Ana ŠpilakChrista Noehammer
Mar 27, 2018·Drug Discovery Today·Michelle C Lowry, Lorraine O'Driscoll

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