Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patients

Pathology International
Sang Hyub LeeHo-Seong Han

Abstract

The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains dismal even after complete resection, with most recurrences occurring within 1-2 years postoperatively. Adenosine triphosphate (ATP)-binding cassette (ABC) transporters have been demonstrated to play major roles in multidrug resistance (MDR) of cancers. In this study, we evaluated the expression statuses and the clinical significance of MDR1 (ABCB1), MDR-associated proteins (MRPs/ABCC) 1, 2 and 3, and breast cancer resistance protein (BCRP/ABCG2) in 67 surgically resected PDACs by immunohistochemistry. MDR1, MRP1, MRP2, MRP3 and BCRP were expressed in 35 (52.2%), 56 (83.6%), 61 (91.0%), 49 (73.1%) and 49 (73.1%) out of 67 cases, respectively. The expression statuses of the MDR-related proteins were positively correlated with each other (P < 0.05). Tumors expressing MRP1 (P= 0.015), MRP2 (P= 0.022) and MRP3 (P < 0.001) demonstrated more frequent perineural invasion. MDR1 expression was significantly correlated with lymphatic invasion (P= 0.047). High BCRP expression in PDAC was a significant prognostic factor for early tumor recurrence (HR = 2.43, P= 0.003) and poor survival (HR = 2.63, P= 0.001). MDR-related proteins are frequently expressed in PDAC, and high BCRP...Continue Reading

References

Apr 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J J LokichJ G Fryer
Mar 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ErlichmanT Elhakim
Feb 1, 1997·World Journal of Surgery·C SpertiS Pedrazzoli
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M KoolP Borst
Oct 3, 2001·The Journal of Biological Chemistry·N ZelcerP Borst
Feb 19, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·George L SchefferRik J Scheper
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Jun 5, 2002·Annual Review of Biochemistry·P Borst, R Oude Elferink
Sep 19, 2003·International Journal of Antimicrobial Agents·Hermann Lage
Jan 7, 2004·Pancreas·Thomas SchaarschmidtRainer Wacke
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Jörg KönigDietrich Keppler
Apr 2, 2005·Nature Reviews. Cancer·Michael DeanSusan Bates
Apr 23, 2005·Toxicology and Applied Pharmacology·Elaine M LeslieSusan P C Cole
Feb 7, 2007·Cancer Research·Chenwei LiDiane M Simeone
Dec 1, 2007·Cancer·Dan S Zuckerman, David P Ryan
Mar 6, 2008·JAMA : the Journal of the American Medical Association·James L Abbruzzese
Sep 12, 2008·Nature Reviews. Cancer·Jane E Visvader, Geoffrey J Lindeman
Dec 17, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Wolfgang HagmannJ Matthias Löhr
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 8, 2009·Methods in Molecular Biology·Chenwei LiDiane M Simeone
Jul 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhong ChenZhongchao Han
Dec 2, 2009·Journal of Korean Medical Science·Kyu-Won JungJin Soo Lee
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 9, 2010·Neoplasia : an International Journal for Oncology Research·Wolfgang HagmannJohannes Matthias Löhr

❮ Previous
Next ❯

Citations

Jul 22, 2014·Frontiers in Biology·Wei Bin FangNikki Cheng
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jun-Feng ZhangJiao Li
Sep 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gabriela Carrasco-TorresVerónica Rocío Vásquez-Garzón
Sep 23, 2014·The AAPS Journal·Qingcheng Mao, Jashvant D Unadkat
Aug 4, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Wilson PetrushnkoAnubhav Mittal
Oct 14, 2014·World Journal of Gastroenterology : WJG·Si-Xue LiuYing-Qiang Zhong
Aug 8, 2019·Journal of Biomedical Materials Research. Part a·Md AquibBo Wang
Aug 15, 2019·Seminars in Cancer Biology·Stefania NobiliEnrico Mini
Jan 18, 2021·European Journal of Medicinal Chemistry·Katja SilbermannMichael Wiese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.