Breast cancer risk after full-term pregnancies among African women from Nigeria, Cameroon, and Uganda

Cancer
Dominique SighokoOlufunmilayo I Olopade

Abstract

The breast cancer (BC) risk profiles of African women differ significantly from those of women of European ancestry. African women are younger at the age of onset and tend to have high parity. The purpose of this study was to examine the relationship between full-term pregnancy (FTP) and the risk of BC. A case-control study was conducted among 1995 women with invasive BC and 2631 controls in Nigeria, Cameroon, and Uganda. Odds ratios (ORs) for individual ages at FTP according to the time since delivery were calculated and adjusted for confounders. A fitted spline model was used to assess the impact of the number of pregnancies on BC risk. In comparison with a nulliparous woman, a parous woman with her first FTP at 20 years showed an OR of 0.76 (95% confidence interval [CI], 0.57-0.99) for developing BC in the following 5 years. Ten years later, this risk was 0.76 (95% CI, 0.58-0.99) and 0.76 (95% CI, 0.58-0.98) for women aged 25 and 30 years, respectively. Similarly, a parous woman with 1 pregnancy had an OR of 0.69 (95% CI, 0.49-0.96), whereas the OR was 0.66 (95% CI, 0.48-0.91) with 2 or 5 pregnancies and 0.67 (95% CI, 0.47-0.94) with 6 pregnancies in comparison with nulliparous women. In contrast to studies in women of Europ...Continue Reading

References

Jan 15, 1992·American Journal of Epidemiology·D R Pathak, A S Whittemore
Dec 1, 1990·International Journal of Epidemiology·C D Drews, S Greeland
Jun 15, 1983·International Journal of Cancer. Journal International Du Cancer·D TrichopoulosS Yuasa
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C HsiehW C Willett
Jul 7, 1994·The New England Journal of Medicine·M LambeH O Adami
Jun 11, 1999·The British Journal of Surgery·C A Adebamowo, O O Adekunle
Feb 7, 2001·American Journal of Epidemiology·W C ChieB MacMahon
Jan 4, 2001·Epidemiology·J Wohlfahrt, M Melbye
Jun 1, 2002·Breast Cancer Research and Treatment·F Clavel-Chapelon, M Gerber
Dec 20, 2002·Cancer·Olufunmilayo I OlopadeCarolyn Whitfield-Broome
Mar 20, 2003·Journal of the National Cancer Institute·Julie R PalmerLynn Rosenberg
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Oct 3, 2007·Breast Cancer Research and Treatment·Dezheng HuoOlufunmilayo I Olopade
Jan 10, 2008·British Journal of Cancer·R L BowenJ L Jones
Feb 28, 2008·British Journal of Cancer·D HuoO I Olopade
Jul 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sarah J LordGiske Ursin
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dezheng HuoOlufunmilayo I Olopade
Feb 18, 2010·International Journal of Cancer. Journal International Du Cancer·Dominique SighokoPierre Hainaut
Dec 31, 2010·Journal of the National Cancer Institute·Xiaohong R YangMontserrat Garcia-Closas
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Feb 25, 2011·Journal of the National Cancer Institute·Amanda I PhippsChristopher I Li
Jan 19, 2012·Cancer·Ahmedin JemalD Maxwell Parkin
Feb 24, 2012·Carcinogenesis·Dezheng HuoOlufunmilayo I Olopade
Jun 29, 2012·Breast Cancer Research and Treatment·Jing ZhangOlufunmilayo I Olopade
Jul 4, 2012·International Journal of Cancer. Journal International Du Cancer·Freddie BrayJacques Ferlay
Mar 16, 2013·The Breast : Official Journal of the European Society of Mastology·Dominique SighokoPierre Hainaut
Jul 3, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Valentina RosatoCarlo La Vecchia
Nov 12, 2013·Journal of Epidemiology and Global Health·Luisa MoralesManuel Bayona

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Citations

Mar 16, 2017·International Journal of Cancer. Journal International Du Cancer·Louise A BrintonJonine D Figueroa
Feb 19, 2020·International Journal of Cancer. Journal International Du Cancer·Jonine D FigueroaUNKNOWN Ghana Breast Health Study Team
Jul 25, 2020·Annals of Global Health·Alfred JathoNoleb Mugume Mugisha
Sep 28, 2017·Breast Cancer Research and Treatment·Shahin SayedMansoor Saleh
Mar 21, 2020·BMC Complementary Medicine and Therapies·Suellen LiOlufunmilayo I Olopade
Apr 22, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shengfeng WangDezheng Huo
Mar 20, 2021·Breast Cancer Research : BCR·Jonine D FigueroaThomas E Rohan

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