Breast cancer risk and imprinting methylation in blood

Clinical Epigenetics
Kristina HarrisonPaul Haggarty

Abstract

Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, providing a plausible mechanism linking known early life factors to cancer risk. This study investigated methylation status of seven imprinted differentially methylated regions-PLAGL1/ZAC1, H19-ICR1, IGF2-DMR2, KvDMR-ICR2, RB1, SNRPN-DMR1 and PEG3-in blood samples from 189 women with the most common type of invasive breast cancer (invasive ductal carcinoma-IDC), 41 women with in situ breast cancer (ductal carcinoma in situ-DCIS) and 363 matched disease-free controls. There was no evidence that imprinted gene methylation levels varied with age (between 25 and 87 years old), weight or height. Higher PEG3 methylation was associated with an elevated risk of IDC (odds ratio (OR) 1.065; 95 % confidence interval (CI) 1.002, 1.132; p = 0.042) and DCIS (OR 1.139; 95 % CI 1.027, 1.263; p = 0.013). The effect was stronger when in situ and invasive breast cancer were combined (OR 1.079; 95 % CI 1.020, 1.142; p = 0.008). DCIS breast cancer risk increased with higher KvDMR-ICR2 methylation (OR 1.395; 95 % CI 1.190, 1.635; p < 0.001) and lo...Continue Reading

References

Jun 1, 1996·Cancer·E B ClausN J Risch
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·M S WolffJ Huff
Sep 6, 2000·British Journal of Cancer·B L StavolaA J Swerdlow
Aug 11, 2001·Science·W ReikJ Walter
Dec 10, 2002·Mechanisms of Ageing and Development·Yasuhito Yuasa
May 3, 2003·Breast Cancer Research and Treatment·Mona OkashaGeorge Davey Smith
Nov 6, 2003·International Journal of Cancer. Journal International Du Cancer·Martin AhlgrenMads Melbye
Jun 1, 2004·Twin Research : the Official Journal of the International Society for Twin Studies·Isabella LocatelliAnatoli I Yashin
Jun 17, 2004·Journal of the National Cancer Institute·Gregory D Leonard, Sandra M Swain
Aug 18, 2004·Biochemical Pharmacology·Moshe SzyfShafaat A Rabbani
Sep 8, 2004·Analytical Biochemistry·Jean-Michel DupontIvo Glynne Gut
Jul 12, 2005·Nature Genetics·Min HuKornelia Polyak
Nov 25, 2005·Cancer Investigation·Michele R FormanYawei Zhang
Dec 22, 2005·Nature Reviews. Genetics·Andrew P FeinbergSteven Henikoff
Oct 3, 2008·PLoS Medicine·Isabel dos Santos SilvaUNKNOWN Collaborative Group on Pre-Natal Risk Factors and Subsequent Risk of Breast Cancer
Apr 29, 2009·Gene·Jennifer M Huang, Joomyeong Kim
Aug 18, 2009·Breast Cancer Research and Treatment·Christopher M HeaphyMarco Bisoffi
Oct 16, 2009·American Journal of Epidemiology·Vanessa CottetMarie-Christine Boutron-Ruault
Dec 5, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Hoi-Hung CheungWai-Yee Chan
Jan 15, 2010·Journal of the National Cancer Institute·Beth A VirnigRobert L Kane
Apr 14, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rudolf P TalensBastiaan T Heijmans
Dec 3, 2010·The Journal of Pathology·Alessandro Bombonati, Dennis C Sgroi
Jan 26, 2011·Expert Reviews in Molecular Medicine·Santiago Uribe-LewisAdele Murrell
Dec 1, 2011·Epigenomics·Sarah DedeurwaerderFrançois Fuks
Jun 5, 2012·Progress in Molecular Biology and Translational Science·Paul Haggarty
Oct 17, 2012·PloS One·Bjorn T AdalsteinssonVilmundur Gudnason
Nov 3, 2012·Lancet·UNKNOWN Independent UK Panel on Breast Cancer Screening
Nov 16, 2012·The American Journal of Clinical Nutrition·Paul HaggartyGeraldine McNeill
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Yin XuBo Chen

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Citations

Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zibo LiJun Wang
Feb 2, 2019·PloS One·Marlene Lorgen-RitchiePaul Haggarty
Nov 30, 2016·Clinical Epigenetics·Qiuqiong TangBarbara Burwinkel
Dec 24, 2019·Frontiers in Bioengineering and Biotechnology·Tongtong ZhuShangwei Ning
Oct 10, 2018·Nature Communications·Tine GoovaertsTim De Meyer
Nov 30, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zhong GuanHermann Brenner

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Methods Mentioned

BETA
PCR
Assay

Software Mentioned

PyroMark Assay Design
SE
PyroMark CpG
STATA

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