Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Parveen BhattiAlice J Sigurdson

Abstract

Genome-wide association studies are discovering relationships between single-nucleotide polymorphisms and breast cancer, but the functions of these single-nucleotide polymorphisms are unknown and environmental exposures are likely to be important. We assessed whether breast cancer risk single-nucleotide polymorphisms interacted with ionizing radiation, a known breast carcinogen, among 859 cases and 1,083 controls nested in the U.S. Radiologic Technologists cohort. Among 11 Breast Cancer Association Consortium risk single-nucleotide polymorphisms, we found that the genotype-associated breast cancer risk varied significantly by radiation dose for rs2107425 in the H19 gene (P(interaction) = 0.001). H19 is a maternally expressed imprinted mRNA that is closely involved in regulating the IGF2 gene and could exert its influence by this or by some other radiation-related pathway.

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Citations

Feb 9, 2012·Journal of the National Cancer Institute·Lois B TravisJohn D Boice
Jan 1, 2014·Health Physics·Lois B TravisJohn D Boice
Oct 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Smita Bhatia
Dec 18, 2013·Seminars in Oncology·Smita Bhatia
Jan 18, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gerard SociéSmita Bhatia
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Sep 6, 2020·The Journal of Gene Medicine·Carolina MathiasJaqueline Carvalho de Oliveira
Apr 13, 2021·Reproductive Sciences·Zahra FalahatiReza Mirfakhraie

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