Breast Cancer Stem Cells.

Biomedicines
Judy S Crabtree, Lucio Miele

Abstract

Breast cancer stem cells (BCSC) have been implicated in tumor initiation, progression, metastasis, recurrence, and resistance to therapy. The origins of BCSCs remain controversial due to tumor heterogeneity and the presence of such small side populations for study, but nonetheless, cell surface markers and their correlation with BCSC functionality continue to be identified. BCSCs are driven by persistent activation of developmental pathways, such as Notch, Wnt, Hippo, and Hedgehog and new treatment strategies that are aimed at these pathways are in preclinical and clinical development.

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Citations

Mar 29, 2019·International Journal of Molecular Sciences·Cristina PorcheriThimios Mitsiadis
Oct 17, 2019·World Journal of Stem Cells·Pia GiovannelliGabriella Castoria
Dec 7, 2019·Current Stem Cell Research & Therapy·Plabon K DasFarhadul Islam
May 7, 2019·International Journal of Experimental Pathology·Hongtao ZhangZhonglian Li
Dec 10, 2020·Nature Reviews. Drug Discovery·Samarpan MajumderLucio Miele
May 7, 2020·Current Cancer Drug Targets·Mamta KumariPiyong Sola
Jan 12, 2021·Molecular Carcinogenesis·Naing L ShanNanjoo Suh
Dec 15, 2020·World Journal of Stem Cells·Gretel Mendoza-AlmanzaJorge Olmos
Dec 15, 2020·World Journal of Stem Cells·Xu Gao, Qiong-Zhu Dong
Mar 24, 2020·Biochemical and Biophysical Research Communications·Chenghuai TangLihua Wan
Apr 4, 2021·Biomolecules·Nadia Flores-HuertaCésar López-Camarillo
May 30, 2021·Medical Oncology·Jacqueline R LimAnn H Kwan
Aug 8, 2021·International Journal of Molecular Sciences·Hsing-Ju Wu, Pei-Yi Chu

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Methods Mentioned

BETA
xenograft
fluorescence-activated cell sorting
nuclear translocation

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