Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

BMC Cancer
Peter F McAnenaM J Kerin

Abstract

Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p < 0.05) with overall survival approaching significance (p = 0.064) compared to concordant luminal A cases (n = 46). Overall receptor discordance rates were: estrogen receptor 20.4% (n = 27), progesterone receptor 37.7% (n = 50) and HER2 3% (n = 4). Loss o...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T W JacobsS J Schnitt
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Aug 23, 2002·Nature·René Bernards, Robert A Weinberg
Mar 14, 2007·Cancer Cell·Michail ShipitsinKornelia Polyak
Nov 2, 2007·International Journal of Cancer. Journal International Du Cancer·Alfredo SantinelliGuidalberto Fabris
May 24, 2008·Advances in Experimental Medicine and Biology·Marie MaynadierMarcel Garcia
Mar 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SimmonsM J Clemons
May 8, 2009·The Journal of Biological Chemistry·Tzu-Hsuan HuangMichael T McManus
Jul 15, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C LiedtkeA M Gonzalez-Angulo
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 23, 2010·Journal of Vascular and Interventional Radiology : JVIR·Sanjay GuptaUNKNOWN Society of Interventional Radiology Standards of Practice Committee
Sep 25, 2010·Breast Cancer Research : BCR·Laurien D C HoefnagelPaul J van Diest
Nov 10, 2010·Breast Cancer Research : BCR·Alastair M ThompsonUNKNOWN Breast Recurrence in Tissues Study Group
Mar 15, 2011·Nature·Nicholas NavinMichael Wigler
Nov 30, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eitan AmirMark Clemons
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda Sofie LindströmJonas Bergh
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Sep 25, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M V DieciV Guarneri
Oct 12, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L D C HoefnagelP J van Diest
Nov 26, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gaetano AurilioFranco Nolè
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jul 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine Van PoznakLyndsay N Harris
Jun 29, 2016·Breast Cancer Research : BCR·Emma H AllottMelissa A Troester
Dec 14, 2016·The New England Journal of Medicine·Antonio C Wolff

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Citations

Sep 12, 2018·Journal of Cancer Research and Clinical Oncology·Lina ShanHongbo Zhu
Sep 23, 2021·Cell Biology International·Mingcheng LiuLiancheng Lei
Jan 16, 2021·Breast Care·Iris HolzerChristian F Singer

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Methods Mentioned

BETA
biopsy

Software Mentioned

PAS
SPSS
Herceptest
MOSAIQ

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