Breast cancer subtypes predispose the site of distant metastases

American Journal of Clinical Pathology
Abha SoniShi Wei

Abstract

The distant organs to which breast cancer preferentially metastasizes are of significant clinical importance. We explored the relationship between the clinicopathologic factors and the common sites of distant metastasis in 531 consecutive patients with advanced breast cancer. Breast cancer subtype as a variable was significantly associated with all five common sites of relapse by multivariate analysis. The luminal tumors were remarkable for their significant bone-seeking phenotype and were less frequently observed in lung, brain, and pleural metastases and less likely to be associated with multiorgan relapse. The HER2 subtype demonstrated a significant liver-homing characteristic. African Americans were significantly less likely to have brain-only metastasis in patients with brain relapse. These findings further articulate that breast cancer subtypes differ not only in tumor characteristics but also in their metastatic behavior, thus raising the possibility that this knowledge could potentially be used in determining the appropriate strategy for follow-up of patients with newly diagnosed breast cancer.

References

Apr 4, 1973·Nature: New Biology·I J Fidler
Aug 30, 2000·Nature·C M PerouD Botstein
Nov 16, 2004·Cancer Cell·Yan M LiMien-Chie Hung
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Mar 7, 2006·Cancer·Kenneth R HessJames L Abbruzzese
Apr 11, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B C PestalozziUNKNOWN International Breast Cancer Study Group (IBCSG)
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marcel SmidJohn A Foekens
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Jan 11, 2007·Oncogene·B SinghA Lucci
Jan 19, 2007·The New England Journal of Medicine·Joan Massagué
Mar 23, 2007·Breast Cancer Research and Treatment·Isabelle SoerjomataramJan Willem W Coebergh
Apr 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andy J MinnJoan Massagué
May 3, 2007·Breast Disease·Diane PalmieriPatricia S Steeg
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie M WuPedram Argani
May 3, 2008·Cancer Research·Marcel SmidJohn W M Martens
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen ChiaKaren Gelmon
Mar 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SimmonsM J Clemons
May 8, 2009·Nature·Paula D BosJoan Massagué
Oct 21, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A NiwińskaK Pogoda
Oct 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J AitkenD Faratian
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hagen KenneckeKaren Gelmon
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Aug 10, 2012·Annals of Surgical Oncology·Brenda DeyarminRachel E Ellsworth
Nov 7, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James L KhatcheressianUNKNOWN American Society of Clinical Oncology
Nov 21, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GuiuJ S Reis-Filho
Feb 9, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Patrycja GazinskaSarah E Pinder
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antonio C WolffUNKNOWN College of American Pathologists
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Sep 19, 2014·World Journal of Gastrointestinal Oncology·Víctor M Castellano-MegíasFrancisco Colina-Ruizdelgado
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GuiuJ S Reis-Filho

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Citations

Jan 20, 2016·Breast Cancer Research : BCR·Isabell WitzelHarriet Wikman
Oct 22, 2015·American Journal of Clinical Pathology·Brandi C McCleskeyShi Wei
Dec 23, 2015·Trends in Cancer·Anna C Obenauf, Joan Massagué
Sep 1, 2015·Seminars in Cancer Biology·Siker KimbungIngrid Hedenfalk
Oct 4, 2016·Pathology, Research and Practice·Tiansheng ShenShi Wei
Oct 9, 2016·Clinical & Experimental Metastasis·Anne Gulbech OrdingHenrik Toft Sørensen
Nov 7, 2016·The Breast : Official Journal of the European Society of Mastology·Catharina BartmannManfred Wischnewsky
Jan 20, 2017·Virchows Archiv : an International Journal of Pathology·István Artúr MolnárAnna-Mária Tőkés
Apr 26, 2017·International Journal of Cancer. Journal International Du Cancer·Akshay A NarkhedeShreyas S Rao
Jan 19, 2017·International Journal of Molecular Sciences·Jodi M SaunusSunil R Lakhani
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·San-Gang WuZhen-Yu He
Oct 3, 2015·Archives of Plastic Surgery·Jun Yong LeeSung-No Jung
Mar 18, 2015·American Journal of Clinical Pathology·Siobhan M O'Connor, Thomas J Lawton
Feb 2, 2018·NPJ Breast Cancer·Amanda ParkesGabriel N Hortobagyi
Mar 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Fredrika SchillPia Burman
Jun 22, 2019·Nature Communications·Shuo WangYu-Mei Feng
Dec 29, 2019·Scientific Reports·David André BarrièrePhilippe Sarret
Jan 3, 2018·International Journal of Molecular Sciences·Thaiz F BorinAli S Arbab
Aug 7, 2019·Neuro-oncology Practice·Dhiego Chaves de Almeida BastosSujit S Prabhu
Mar 28, 2020·American Society of Clinical Oncology Educational Book·Allen LiZahi I Mitri

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