Breast cancer with different prognostic characteristics developing in Danish women using hormone replacement therapy

British Journal of Cancer
C StahlbergE Lynge

Abstract

The aim of this study is to investigate the risk of developing prognostic different types of breast cancer in women using hormone replacement therapy (HRT). A total of 10 874 postmenopausal Danish Nurses were followed since 1993. Incident breast cancer cases and histopathological information were retrieved through the National Danish registries. The follow-up ended on 31 December 1999. Breast cancer developed in 244 women, of whom 172 were invasive ductal carcinomas. Compared to never users, current users of HRT had an increased risk of a hormone receptor-positive breast cancer, but a neutral risk of receptor-negative breast cancer, relative risk (RR) 3.29 (95% confidence interval (CI): 2.27-4.77) and RR 0.99 (95% CI: 0.42-2.36), respectively (P for difference=0.013). The risk of being diagnosed with low histological malignancy grade was higher than high malignancy grade with RR 4.13 (95% CI: 2.43-7.01) and RR 2.17 (95% CI: 1.42-3.30), respectively (P=0.063). For breast cancers with other prognostic characteristics, the risk was increased equally for the favourable and non favourable types. Current users of HRT experience a two- to four-fold increased risk of breast cancer with various prognostic characteristics, both the favou...Continue Reading

References

Mar 1, 1982·British Journal of Cancer·J L HaybittleK Griffiths
Jan 1, 1996·Breast Cancer Research and Treatment·C MagnussonI Persson
Jan 1, 1997·British Journal of Cancer·C J FisherI S Fentiman
Jan 1, 1997·British Journal of Cancer·J KolliasR W Blamey
Mar 19, 1999·Annals of Surgical Oncology·M M BilimoriaD P Winchester
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·C MagnussonI Persson
Feb 5, 2000·JAMA : the Journal of the American Medical Association·C SchairerR Hoover
Feb 17, 2000·Journal of the National Cancer Institute·R K RossM C Pike
Mar 15, 2000·Acta Obstetricia Et Gynecologica Scandinavica·Y A HundrupJ Philip
Jul 25, 2000·Journal of the National Cancer Institute·C MagnussonH O Adami
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giske UrsinRonald K Ross
Feb 12, 2002·Maturitas·Pia Eiken, Niels Kolthoff
Apr 23, 2002·American Journal of Obstetrics and Gynecology·Eva LundströmBo von Schoultz
Jun 4, 2002·Statistical Methods in Medical Research·Per Kragh AndersenSusanne Rosthøj
Oct 24, 2002·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M AlkhalafS Karam
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Rowan T ChlebowskiUNKNOWN WHI Investigators
Jun 26, 2003·JAMA : the Journal of the American Medical Association·Christopher I LiJanet R Daling
Sep 25, 2003·Breast Cancer Research and Treatment·Dorota M GertigAnne M Kavanagh
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karla KerlikowskePatricia A Carney
Mar 5, 2004·International Journal of Cancer. Journal International Du Cancer·Claudia StahlbergBent Ottesen

❮ Previous
Next ❯

Citations

Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agnès FournierFrançoise Clavel-Chapelon
Apr 3, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Polly A NewcombWalter C Willett
Sep 23, 2008·Breast Cancer Research : BCR·Lena U RosenbergPer Hall
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Louise A BrintonJames V Lacey
Apr 10, 2009·International Journal of Cancer. Journal International Du Cancer·Thomas DünnebierUte Hamann
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Signe BorgquistJonas Manjer
Dec 17, 2008·Pharmacoepidemiology and Drug Safety·Lars Hougaard NielsenNiels Keiding
Oct 11, 2007·Menopause : the Journal of the North American Menopause Society·Leon Speroff
Sep 10, 2005·Human Reproduction Update·John A CollinsPier Giorgio Crosignani
Dec 7, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Rodney BaberMichelle Kwik
Jul 7, 2011·International Journal of Cancer. Journal International Du Cancer·Solveig HofvindSidsel Graff-Iversen
Aug 6, 2013·Climacteric : the Journal of the International Menopause Society·C AntoineS Rozenberg
Aug 24, 2017·BMC Cancer·Zorana Jovanovic AndersenElsebeth Lynge
Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·S Shapiro
Jun 17, 2011·Pathology Oncology Research : POR·Jasmina-Ziva CerneKsenija Gersak
Jun 23, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gad RennertHedy S Rennert
Oct 7, 2018·Breast Cancer Research : BCR·Zorana Jovanovic AndersenElsebeth Lynge
Sep 6, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Abenaa M BrewsterMelissa L Bondy
Sep 8, 2020·Journal of Menopausal Medicine·UNKNOWN Academic Committee of the Korean Society of MenopauseTak Kim
Apr 2, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tracy E SlangerDieter Flesch-Janys

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement therapy
hysterectomies

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
J ManjerL Janzon
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Lena U RosenbergCecilia Magnusson
© 2022 Meta ULC. All rights reserved