PMID: 3012934Mar 1, 1986Paper

Breast cancer with reactive multinucleated giant cells: report of three cases

Acta Pathologica Japonica
K IchijimaS Matsuo

Abstract

We report here three cases of breast cancer with reactive multinucleated giant cells. The patients were among the 605 patients with breast cancer seen in the past 17 years at Tenri Hospital; the incidence of this variety of breast cancer was 0.5%. Enzyme histochemical and electron microscopic examination suggested that the giant cells were of histiocytic origin. However, results of immunohistochemical technique, S-100 protein, lysozyme, nonspecific cross-reacting antigen with carcinoembryonic antigen, alpha-1-antitrypsin, and alpha-1-antichymotrypsin, all currently used as markers of histiocytes, were negative. Because of the rarity of this variety of breast cancer, the biological significance of these unusual findings remains unknown.

References

May 13, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·S M FactorS Biempica
Sep 1, 1979·American Journal of Clinical Pathology·N T Agnantis, P P Rosen
Nov 1, 1984·Acta Pathologica Japonica·S KobayashiM Matsuyama
Jan 1, 1983·Acta Pathologica Japonica·S WatanabeH Sakuma
Jul 1, 1981·Southern Medical Journal·A LevinP Tachmes
Mar 1, 1980·Acta Pathologica Japonica·H HashimotoM Enjoji

Citations

Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M SaimuraT Nanasawa
May 15, 2002·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Riwa KishimotoMichio Shimizu
Nov 1, 1993·Journal of Comparative Pathology·L Della SaldaP S Marcato
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·L M GjerdrumF B Sørensen

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