Breast Carcinoma: Updates in Molecular Profiling 2018

Clinics in Laboratory Medicine
Sudeshna BandyopadhyayRouba Ali-Fehmi

Abstract

The most significant contribution of molecular subtyping of breast carcinomas has been the identification of estrogen-positive and estrogen-negative tumor subtypes. Knowledge of genetic alterations in these tumors will help clinicians identify novel therapeutic targets. Understanding the progression pathways involved in the transition of in situ carcinoma to invasive carcinoma might lead to efficient risk stratification in these patients. The Cancer Genome Analysis Network has collected genomic and epigenomic data to provide comprehensive information regarding carcinogenesis and pathway interactions. Such information improves understanding of the disease process and also provides more accurate information toward identifying targetable mutations for treatment.

Citations

Jul 4, 2019·Virchows Archiv : an International Journal of Pathology·Fabio AimiLaurence de Leval
Nov 23, 2019·Non-coding RNA·Yajuan XiaoZhishan Wang
Nov 13, 2020·Journal of Cancer Epidemiology·Nadeem BilaniZeina Nahleh
Aug 26, 2020·Archives of Medical Research·Luiz Paulo Guido, Carmen Gomez-Fernandez

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