Breast conservation surgery and interstitial brachytherapy in the management of locally recurrent carcinoma of the breast: the Allegheny General Hospital experience

Brachytherapy
Mark TrombettaDavid Parda

Abstract

To evaluate lumpectomy followed by interstitial brachytherapy as an acceptable salvage therapy for women who have developed localized recurrence of breast cancer after conservation surgery and postoperative external radiotherapy. Between 1/1998 and 10/2006, 21 patients with T0 or T1 in-breast recurrence of carcinoma were offered interstitial low-dose rate brachytherapy after tumor re-excision as an alternative to salvage mastectomy. All patients had failed lumpectomy followed by standard postoperative external beam radiotherapy (range, 5000-6040cGy) as treatment for the initial breast carcinoma. Seven recurred as ductal carcinoma in situ, 2 as infiltrating lobular carcinoma, and 12 as recurrent invasive carcinoma. The recurrent tumors were excised with final margins of resection free of residual disease per National Surgical Adjuvant Breast and Bowel Project definition. Tumor bed implantation was then carried out with an interstitial technique using (192)Ir with the target volume consisting of the tumor bed plus a minimum 1.0-cm clinical margin. The required minimum dose delivered to the target volume was 4500-5000cGy (range, 4500-5530). Twenty of 21 patients were free of local disease with a median observation time of 40 month...Continue Reading

References

Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B L FowbleR L Goodman
Jul 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B G HafftyC McKhann
Jun 1, 1989·American Journal of Clinical Oncology·Z PetrovichM Astrahan
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·A RechtJ R Harris
Jun 1, 1996·Cancer·M J SilversteinD N Poller
Jan 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E E MullenW D Bloomer
Sep 7, 2000·Journal of the National Cancer Institute·J H RowlandP A Ganz
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F A ViciniA Martinez
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·K L BaglanF A Vicini
Aug 23, 2001·International Journal of Radiation Oncology, Biology, Physics·T DoyleL J Solin
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Melvin Deutsch
Jan 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Kathy L BaglanFrank A Vicini
Dec 14, 2004·International Journal of Radiation Oncology, Biology, Physics·Jean-Michel Hannoun-LeviDidier Cowen
Mar 1, 2006·International Journal of Radiation Oncology, Biology, Physics·Robert R KuskeR M Wilenzick
Jul 26, 2006·International Journal of Radiation Oncology, Biology, Physics·Jessica R HiattDavid E Wazer
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun

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Citations

Oct 1, 2013·The Breast : Official Journal of the European Society of Mastology·Felix SedlmayerGerd Fastner
Mar 8, 2013·Cancer Treatment Reviews·Jean-Michel Hannoun-LeviAdel Courdi
May 27, 2014·Annals of Surgical Oncology·Caprice C GreenbergRinaa S Punglia
Dec 16, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J CastelliJ-M Hannoun-Lévi
Mar 5, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wolfgang HarmsUNKNOWN Breast Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO)
Nov 6, 2009·Current Problems in Surgery·John T VettoArpana Naik
Sep 13, 2008·Brachytherapy·Mark TrombettaDavid Parda
Jun 8, 2013·The Breast Journal·Amy E E BurgerGabor Peley
Jun 1, 2010·Journal of Surgical Oncology·Seema A Khan, Firas Eladoumikdachi
Sep 13, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Daniela Kauer-DornerWolfgang Dörr
Aug 3, 2018·Breast Care·Daniela Kauer-Dorner, Daniel Berger
Aug 20, 2021·Advances in Radiation Oncology·Michael J LaRiviereGary M Freedman

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