Abstract
We carried out a meta-analysis to determine the effectiveness of breast conservation therapy (BCT) or mastectomy (MT) for stage I or stage II breast cancer. A fully recursive literature search was conducted in the Cochrane Controlled Trials Register Databases, Medline, EMBASE and Chinese Biomedical Literature Database in any language. Randomized controlled trials (RCTs) were considered for inclusion. Analyses were carried out using RevMan software. In all, 18 RCTs including a total of 9388 patients were included. The meta-analysis showed that the overall survival in 3, 5, 10, 15 and 20 years and the locoregional recurrence rate in 3, 5, 15 and 20 years were not statistically significantly different between group BCT and group MT, but 10-year locoregional recurrence rate increased in group BCT. The sensitivity analysis indicated that both overall survival and locoregional recurrence rate were not statistically significant difference between group BCT and group MT. In the subgroup analysis, there was no significant difference in OS and locoregional recurrence rate between group BCT and group MT, but 20-year locoregional recurrence rate was statistically significantly higher in group BCT than group MT for women with tumors 2 cm or...Continue Reading
References
Jun 1, 1977·Cancer·U VeronesiL Sultan
Jun 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S LichterS M Swain
Dec 1, 1984·Cancer·E D MontagueM M Romsdahl
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiF Rilke
Apr 6, 1995·The New England Journal of Medicine·J A JacobsonP Okunieff
Jan 1, 1994·World Journal of Surgery·B Fisher, S Anderson
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R ArriagadaG Contesso
Jul 1, 1997·Breast Cancer Research and Treatment·H D LeeK K Oh
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F E van LeeuwenB M Aleman
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A J SwerdlowD C Linch
Jul 25, 2000·Journal of the National Cancer Institute·J A van DongenH Bartelink
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Aug 23, 2002·The New England Journal of Medicine·Bernard FisherNorman Wolmark
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M FreedmanN Nicoloau
Oct 5, 2002·CA: a Cancer Journal for Clinicians·Monica MorrowUNKNOWN College of American Pathology
Oct 24, 2002·The New England Journal of Medicine·Umberto VeronesiEttore Marubini
Dec 20, 2002·Cancer·Andrew C NeuschatzDavid E Wazer
Feb 5, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I S FentimanUNKNOWN EORTC
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 9, 2003·The New England Journal of Medicine·Umberto VeronesiRoberto Gennari
Aug 12, 2003·Cancer·Matthew M PoggiRosemary M Altemus
Oct 29, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R ArriagadaT Tursz
Jan 21, 2004·The Breast : Official Journal of the European Society of Mastology·I S Fentiman
Jan 22, 2004·Journal of the National Cancer Institute·Vincent Vinh-Hung, Claire Verschraegen
Jan 5, 2006·Journal of the National Cancer Institute·Val GebskiAllan O Langlands
Jun 28, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN EORTC Breast Cancer Cooperative GroupEmiel J Th Rutgers
Citations
Feb 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Paula ManchonUNKNOWN Breast Cancer OncoGuia Group
Nov 6, 2010·Updates in Surgery·Arianna RubinoLeandro Gennari
Oct 14, 2011·Updates in Surgery·Domenico Gerbasi
Oct 23, 2013·Surgical Oncology·Jin WangMengyang Di
Jan 29, 2009·Human Reproduction Update·M HickeyM Friedlander
Mar 15, 2012·Onkologie·Xiaopeng CaiXinyu Zheng
Aug 25, 2010·Annals of Surgical Oncology·Oded OlshaItamar Ashkenazi
Jun 19, 2007·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Fengling CuiXiaojun Yao
Mar 23, 2011·Future Oncology·David A ReardonRoger Stupp
Aug 6, 2014·Academic Radiology·Anton OseledchykManuel Debald
Jul 22, 2014·American Journal of Surgery·Ahmad KavianiRemy J Salmon
Jul 18, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xiaoling WeiZhiliang Jiang
Feb 5, 2014·Gaceta sanitaria·Ester Angulo-PueyoEnrique Bernal-Delgado
Jun 10, 2015·Cirugia y cirujanos·Santiago Sherwell-CabelloSergio Rodríguez-Cuevas
Apr 22, 2015·International Journal of Surgery Case Reports·Krishna N PundiDavid R Farley
Apr 19, 2015·Implementation Science : IS·Theresa Montini, Ian D Graham
Dec 18, 2014·Archives of Gynecology and Obstetrics·Fabienne Dominique SchwabUwe Güth
Aug 25, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M J Bown, A J Sutton
Jul 4, 2012·Oncology Nursing Forum·Maureen CampesinoRobert S Krouse
Jun 2, 2016·Breast Cancer Research and Treatment·Yan ChenKe-Hu Yang
Oct 26, 2016·American Journal of Surgery·Erin P WardSarah Blair
Jul 13, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Soichi Yabuki
May 13, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Yew-Ching TehCheng-Har Yip
Mar 31, 2019·Journal of Cancer Research and Clinical Oncology·Vinzenz VoelkelSabine Siesling
Aug 24, 2017·Journal of Global Oncology·Ambakumar NandakumarKondalli Lakshminarayana Sudarshan
Oct 28, 2019·Annals of Surgical Oncology·Kevin M BoehmAlexander J Swistel
Dec 29, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Ping YuFeng Ye
Feb 27, 2021·ANZ Journal of Surgery·Christopher G Harris, Guy D Eslick
Aug 16, 2021·The Journal of Surgical Research·Mohammadreza TabaryAhmad Kaviani