Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer

The Breast Journal
L KrishnanE C Krishnan

Abstract

Radiotherapy after breast-conserving surgery increases local control. We tested the feasibility of limited surgery with tumor bed irradiation only with 192Ir in a selected group of patients with stage I breast cancer. Twenty-five breasts in 24 women more than 60 years old with low- or intermediate-grade stage I tumors were treated with placement of interstitial catheters at the time of lumpectomy and axillary node dissection. This procedure was followed by after-loading with low-dose 192Ir to deliver 20-25 Gy to the tumor bed over 24-48 hours. There were neither local recurrences in the breast nor distant recurrences at a median follow-up of 47 months (range 25-90 months). Cosmetic appearance ranged from very good to excellent. There were no long-term complications. It is feasible to treat a select group of patients with tumor bed irradiation, using relatively low doses of interstitial irradiation, with excellent local control and no significant morbidity.

References

Apr 23, 1992·The New England Journal of Medicine·D C FarrowJ M Samet
Apr 23, 1992·The New England Journal of Medicine·A B NattingerJ S Goodwin
Jun 11, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A S LichterS M Swain
Jan 16, 1991·JAMA : the Journal of the American Medical Association
Feb 1, 1990·International Journal of Radiation Oncology, Biology, Physics·E C KrishnanW R Jewell
Feb 21, 1990·Journal of the National Cancer Institute·UNKNOWN Uppsala-Orebro Breast Cancer Study Group
Mar 1, 1989·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·D SarrazinJ Lacour
Sep 1, 1974·The British Journal of Radiology·C G Orton
Jul 1, 1973·The British Journal of Radiology·C G Orton, F Ellis
Jan 1, 1980·International Journal of Radiation Oncology, Biology, Physics·B PierquinS Hannoun
Nov 30, 1995·The New England Journal of Medicine·UNKNOWN Early Breast Cancer Trialists' Collaborative Group
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiF Rilke
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·G G RibeiroS S Banerjee
Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I S FentimanR D Rubens
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G LiljegrenH O Adami

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Citations

Sep 28, 2005·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·María Concepción López CarrizosaJosé María Delgado Pérez
Feb 20, 2009·International Journal of Clinical Oncology·Csaba Polgár, Tibor Major
Feb 9, 2006·Current Oncology Reports·Alphonse G Taghian, Abram Recht
Dec 31, 2003·International Journal of Radiation Oncology, Biology, Physics·Roberto J SantiagoLawrence J Solin
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·Oscar E StreeterKristin A Skinner
Mar 9, 2004·The Lancet Oncology·Jayant S VaidyaBasil Hilaris
Apr 6, 2004·Brachytherapy·Douglas W ArthurUNKNOWN American Brachytherapy Society
Apr 6, 2004·Brachytherapy·Douglas W ArthurUNKNOWN American Brachytherapy Society
Nov 19, 2003·Breast Cancer Research and Treatment·J M Hannoun-LeviJ P Gerard
Nov 3, 2005·Nature Clinical Practice. Oncology·Rajiv Sarin
Feb 5, 2004·Journal of the National Cancer Institute·P WallnerUNKNOWN Workshop Participants
Dec 20, 2011·Journal of the National Cancer Institute·Jona A HattangadiRinaa S Punglia
Sep 22, 2006·Current Opinion in Oncology·Erik Van Limbergen, Caroline Weltens
Apr 13, 2004·Annals of Surgery·Henry M KuererFrank A Vicini
Feb 24, 2005·The Breast Journal·Martin Keisch, Frank Vicini
Nov 2, 2011·The Breast : Official Journal of the European Society of Mastology·Mattia IntraUmberto Veronesi
Aug 6, 2011·Brachytherapy·Jaroslaw T Hepel, David E Wazer
Jun 24, 2009·International Journal of Radiation Oncology, Biology, Physics·Benjamin D SmithJay R Harris
Sep 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Birgitte V OffersenJens Overgaard
Aug 12, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yazid BelkacémiEric Lartigau
Apr 16, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Bengt JohanssonJan Persliden
Nov 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Laurie W CuttinoDouglas W Arthur
Dec 19, 2007·International Journal of Radiation Oncology, Biology, Physics·Kyle E RusthovenCharles E Leonard
Nov 6, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·Y BelkacémiJ-B Dubois
Jan 27, 2007·Current Problems in Cancer·Gregory M Chronowski, Thomas A Buchholz
Jan 20, 2007·International Journal of Radiation Oncology, Biology, Physics·Charles LeonardJanis Kondrat
Nov 28, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Oliver J OttVratislav Strnad
Dec 21, 2013·CA: a Cancer Journal for Clinicians·Reshma Jagsi
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Jennifer L HarperWilliam E Gillanders
Sep 29, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J M Hannoun-Lévi, H Marsiglia
Jan 28, 2006·The Breast : Official Journal of the European Society of Mastology·J BernierU Veronesi

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