Breast Edema Following Breast-Conserving Surgery and Radiotherapy: Patient-Reported Prevalence, Determinants, and Effect on Health-Related Quality of Life

JNCI Cancer Spectrum
Danny A Young-AfatHelena M Verkooijen

Abstract

The association between lymphedema of the arm and impaired health-related QoL (HR-QoL) has led to changes in clinical practice. However, data on lymphedema of the breast (ie, breast edema) are lacking. We prospectively evaluated patient-reported prevalence and determinants of breast edema and its effect on patient-reported HR-QoL and breast pain. We prospectively included 836 patients undergoing breast-conserving surgery followed by radiotherapy between October 2013 and October 2016 (UMBRELLA cohort). Patient-reported breast edema, HR-QoL, and breast pain were assessed by means of European Organisation for Research and Treatment of Cancer-C30/BR23 before starting radiotherapy and at 3, 6, 12, and 18 months thereafter. We assessed which patient, tumor, and treatment characteristics were associated with breast edema. With mixed-effects models, we assessed the impact of breast edema on patient-reported HR-QoL domains and breast pain over time, adjusting for confounders. Within a median follow-up of 28 months (interquartile range [IQR] = 15), 207 (24.8%) patients reported breast edema at some point in time. Prevalence of breast edema was highest at 6 months (12.4%, 95% confidence interval [CI] = 10.0 to 14.7). Larger tumor size, on...Continue Reading

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Citations

Aug 20, 2020·Breast Cancer Research and Treatment·S L KilbreathD Black
Aug 5, 2020·Current Breast Cancer Reports·Laura S Dominici, Shoshana M Rosenberg
Mar 25, 2021·Lymphatic Research and Biology·Harvey N MayrovitzDaniel N Weingrad
Mar 30, 2021·Archives of Physiotherapy·Hanne VerbelenNick Gebruers
Dec 29, 2020·Clinical Breast Cancer·Mohamed AbouelazayemSherif Monib
Aug 4, 2021·Journal of Plastic Surgery and Hand Surgery·Linda TallrothMagnus Becker

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Methods Mentioned

BETA
biopsy
dissection

Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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