Breast implant-associated anaplastic large cell lymphoma: a case report and literature review

Aesthetic Plastic Surgery
Mei-Ju HwangGuy D Sterne

Abstract

Breast implant-associated anaplastic large cell lymphoma (ALCL) is a rare new clinical entity. The incidence is 0.3 % per 100,000 women per year. Patients present with non-specific implant-related complications resulting in delayed diagnosis. We present such a case to raise awareness and discuss management. A 48-year-old female presented with a 3-month history of left breast pain and swelling. She had undergone multiple bilateral augmentations 8 years previously. Triple assessment revealed a seroma, and a magnetic resonance imaging scan excluded implant rupture. Cytology showed a typical cells with mitotic activity which lead to removal of implants and a left capsulectomy. Final histology revealed an anaplastic lymphoma kinase (ALK) negative ALCL confined to the capsule. A computerised tomography scan and bone marrow biopsy excluded systemic disease, but due to later identified B symptoms, she received CHOP chemotherapy under the care of the haematologists. ALK-negative ALCL is associated with breast implants, and any persistent late onset seroma or breast symptoms should raise the suspicion of ALK-negative ALCL as a differential diagnosis. The recommended treatment is surgical removal of the implant including a full capsulecto...Continue Reading

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Citations

Mar 10, 2016·Breast Cancer Research and Treatment·M OrcianiG Di Benedetto
Sep 4, 2015·Journal of Autoimmunity·Mojca BizjakYehuda Shoenfeld
Aug 19, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Guillermo Ramos-GallardoCesar Torres-Rivero
Sep 16, 2017·Plastic and Reconstructive Surgery·Campanale AntonellaMarletta Marcella
Dec 28, 2017·Plastic and Reconstructive Surgery·Antonella CampanaleMarcella Marletta
Oct 3, 2017·Proceedings·Lindsay KeithPaul Pin
Nov 18, 2018·Inflammation·Monia OrcianiRoberto Di Primio
Dec 28, 2017·Plastic and Reconstructive Surgery·Maurizio Bruno NavaNicola Rocco
Jun 19, 2020·Case Reports in Pathology·P L MooriJ Iddon
Aug 1, 2020·Clinical Oncology : a Journal of the Royal College of Radiologists·M CoA Kwong

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