Breast Implant-associated Anaplastic Large Cell Lymphoma Incidence: Determining an Accurate Risk.

Annals of Surgery
Jonas A NelsonColleen M McCarthy

Abstract

This study sought to estimate the incidence and incidence rate of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) at a high-volume single institution, which enables vigorous long-term follow-up and implant tracking for more accurate estimates. The reported incidence of BIA-ALCL is highly variable, ranging from 1 in 355 to 1 in 30,000 patients, demonstrating a need for more accurate estimates. All patients who underwent implant-based breast reconstruction from 1991 to 2017 were retrospectively identified. The incidence and incidence rate of BIA-ALCL were estimated per patient and per implant. A time-to-event analysis was performed using the Kaplan-Meier estimator and life table. During the 26-year study period, 9373 patients underwent reconstruction with 16,065 implants, of which 9589 (59.7%) were textured. Eleven patients were diagnosed with BIA-ALCL, all of whom had a history of textured implants. The overall incidence of BIA-ALCL was 1.79 per 1000 patients (1 in 559) with textured implants and 1.15 per 1000 textured implants (1 in 871), with a median time to diagnosis of 10.3 years (range, 6.4-15.5 yrs). Time-to-event analysis demonstrated a BIA-ALCL cumulative incidence of 0 at up to 6 years, increasing t...Continue Reading

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Citations

Mar 25, 2021·Plastic and Reconstructive Surgery·Brett T PhillipsArun K Gosain
May 25, 2021·Journal of General Internal Medicine·Cayla D McKernanJonas A Nelson
Jun 27, 2021·Annals of Surgical Oncology·Casimir A E KouwenbergMarc A M Mureau
Aug 5, 2021·Plastic and Reconstructive Surgery·Stefan DabicJonas A Nelson

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