Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management

Histopathology
Emad A RakhaIan O Ellis

Abstract

Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include bio...Continue Reading

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Citations

Mar 19, 2016·Diagnostic Cytopathology·Elia GuadagnoImmacolata Cozzolino
Sep 30, 2016·Archives of Pathology & Laboratory Medicine·Julie M Jorns
Mar 15, 2018·Histopathology·Guillaume BataillonAnne Vincent-Salomon
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Nov 29, 2017·Pathology·Emad A Rakha, Ian O Ellis
Apr 9, 2021·Histopathology·Emad RakhaCecily Quinn
Nov 5, 2021·Virchows Archiv : an International Journal of Pathology·Janina KulkaSigurd F Lax

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