Breast milk lymphocyte response to K1 antigen of Escherichia coli.

Infection and Immunity
M A KellerM E Miller

Abstract

Comparison milk and blood lymphocyte blastogenic responses to the K1 antigen of Escherichia coli and lipopolysaccharide (LPS) from E. coli O127,B8 were examined in 16 postpartum women by [3H]thymidine uptake. Rabbit hemolysincoated sheep erythrocyte monolayers were used to deplete macrophages from milk lymphocyte preparations and to enrich for T lymphocytes in order to make milk preparations more comparable to blood preparations. Response was defined as a stimulation index of greater than or equal to 2.0. There was no evidence of selective response to K1 antigen by milk lymphocytes, since both blood and milk lymphocytes responded in four women and neither blood nor milk lymphocytes responded in nine. Milk lymphocytes alone responded to K1 in one woman, whereas blood lymphocytes alone responded in two women. Additional nonpaired milk or blood cultures were available from three women. None of these responded to K1 antigen. Corresponding lymphocyte cultures were stimulated with LPS. A positive K1 response was always accompanied by an LPS response, and the LPS response correlated with the K1 response in 17 of 19 women. Stool cultures examined with an antiserum agar showed no correlation between the presence of K1 E. coli in the sto...Continue Reading

References

Apr 1, 1977·Journal of Dairy Science·M J Parmely, A E Beer
Nov 1, 1977·The Journal of Experimental Medicine·M E RouxM E Lamm
Oct 30, 1975·Nature·R M GoldblumA Sohl-Akerlund
Apr 1, 1974·European Journal of Immunology·G Brown, M F Greaves
Jun 1, 1974·European Journal of Immunology·D Guy-GrandP Vassalli
Jul 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J M ChillerW O Weigle
Nov 1, 1974·Clinical Immunology and Immunopathology·E Diaz-Jouanen, R C Williams

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Citations

May 1, 1985·Acta paediatrica Scandinavica·J W Lawton, A B Kolstø Otnaess
Jul 5, 2002·Journal of Virology·Steffanie SabbajGrace M Aldrovandi
Jun 1, 1982·Immunology Today·L Å Hanson

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