Breast milk retinol and plasma retinol-binding protein concentrations provide similar estimates of vitamin A deficiency prevalence and identify similar risk groups among women in Cameroon but breast milk retinol underestimates the prevalence of deficiency among young children

The Journal of Nutrition
Reina Engle-StoneKenneth H Brown

Abstract

Breast milk vitamin A (BMVA) has been proposed as an indicator of population vitamin A status but has rarely been applied in large-scale surveys or compared with conventional vitamin A biomarkers. We assessed the prevalence of, and risk factors for, low BMVA and its relation to vitamin A intake, plasma retinol-binding protein (pRBP), and markers of inflammation in a national survey in Cameroon. We randomly selected 30 clusters in each of 3 strata (South, North, and Cities). Casual milk samples were collected from approximately 5 women per cluster (n = 440). pRBP, plasma C-reactive protein (pCRP), plasma α1-acid glycoprotein (pAGP), and 24-h vitamin A intake were assessed in 10 women aged 15-49 y and 10 children aged 12-59 mo per cluster, including a subset of lactating women (n = 253). Low BMVA was infrequent: 7.2% (95% CI: 4.7, 9.8) of values were <1.05 μmol/L, and 9.3% (95% CI: 5.8, 12.7) were <8 μg/g fat, consistent with the low prevalence of pRBP <0.78 μmol/L among women (< 5%) but lower than the prevalence of pRBP <0.83 μmol/L among children (35%). Risk factors for both low BMVA and pRBP included living in the North and low maternal education. BMVA was positively associated with inflammation-adjusted pRBP among women in th...Continue Reading

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Citations

May 28, 2015·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nermin TanikLevent Ertugrul Inan
Apr 14, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kamisha L Johnson-DavisElizabeth L Frank
Jun 19, 2010·Experimental Biology and Medicine·Sara A ArscottSherry A Tanumihardjo
Sep 8, 2017·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Mojtaba KeikhaRoya Kelishadi
May 16, 2014·The Cochrane Database of Systematic Reviews·Evan Mayo-WilsonZulfiqar A Bhutta
Apr 3, 2015·The Journal of Nutrition·Daniel J RaitenUNKNOWN INSPIRE Consultative Group
Mar 26, 2016·The Cochrane Database of Systematic Reviews·Julicristie M OliveiraChristine E East
Dec 5, 2019·Annals of the New York Academy of Sciences·Stephen A VostiKenneth H Brown
May 31, 2018·Advances in Nutrition·Daniela HampelLindsay H Allen
Oct 2, 2020·Current Developments in Nutrition·Bryan M GannonSaurabh Mehta
Oct 10, 2018·European Journal of Clinical Nutrition·Zeweter AbebeKaleab Baye

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