Breast reconstruction and adjuvant therapy: A systematic review of surgical outcomes

Journal of Surgical Oncology
Bassim El-SabawiKetan M Patel

Abstract

The impact of adjuvant therapy on the surgical outcomes following breast reconstruction is poorly understood. The purpose of this systematic review was to evaluate surgical outcomes following autologous and prosthetic reconstruction in the setting of post-mastectomy radiation therapy (PMRT) and adjuvant chemotherapy. A systematic review of the English literature published from 2000 to 2015 in the Pubmed/MEDLINE database was performed to identify all manuscripts reporting outcome of breast reconstruction in patients receiving PMRT and/or adjuvant chemotherapy. Sixty-two manuscripts met the criteria for inclusion. This included 56 manuscripts (5437 patients) evaluating patients treated with PMRT and 11 manuscripts (820 patients) evaluating patients treated with chemotherapy. Pooled analysis of the PMRT cohort revealed significantly higher weighted incidences of re-operation (P < 0.0001), total complications (P < 0.0001), and reconstructive failure (P < 0.0001) in prosthetic reconstruction compared to autologous. There was little evidence to suggest that postoperative chemotherapy is associated with poorer overall outcomes. PMRT was associated with an increased incidence of adverse events when compared to chemotherapy. There was l...Continue Reading

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Citations

Jan 12, 2016·Journal of Surgical Oncology·Bassim El-SabawiKetan M Patel
Jun 8, 2018·Plastic and Reconstructive Surgery·Sarah M ElswickValerie Lemaine
Aug 23, 2018·Cancer Control : Journal of the Moffitt Cancer Center·Johanna H YunAmber G Orman
Oct 3, 2019·Plastic and Reconstructive Surgery·Jorge Lujan-HernandezJanice F Lalikos
May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dean A ShumwayReshma Jagsi
Jul 17, 2020·Journal of Surgical Oncology·Justin M BroylesMark V Schaverien
Feb 20, 2016·Plastic and Reconstructive Surgery. Global Open·Jean-Claude D Schwartz, Piotr P Skowronski
Oct 25, 2017·Plastic and Reconstructive Surgery·Jonas A Nelson, Joseph J Disa
Jun 9, 2020·Breast Cancer Research and Treatment·Meghan E VidtKathryn H Schmitz
Jan 22, 2017·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Kenji SekiguchiHideko Yamauchi
Mar 27, 2018·Journal of Surgical Oncology·Anmol S ChatthaSamuel J Lin
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Jan 26, 2021·Advances in Radiation Oncology·Mutlay SayanBruce G Haffty
Jan 21, 2021·Annals of Plastic Surgery·Joseph A KellingAndrew Y Zhang
Jul 25, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Po Hsiang Shawn YuanKathryn V Isaac
Aug 23, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Damaris Patricia RojasBarbara Alicja Jereczek-Fossa

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