Breast reconstruction and risk of arm lymphedema development: A meta-analysis

Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS
Charalampos SiotosGedge D Rosson

Abstract

Lymphedema remains a significant complication following breast cancer surgery when there is axillary lymph node intervention. Previous systematic reviews have identified risk factors for breast cancer-related lymphedema, including increased BMI, number of lymph nodes dissected and radiotherapy. However, they have not examined the effect of breast reconstruction on lymphedema occurrence. In this systematic review and meta-analysis, we sought to evaluate the association between breast reconstruction (BR) and lymphedema. We searched PubMed (1966-2016), Embase (1966-2016), Scopus (2004-2016) and Google Scholar (2004-2016) for studies involving breast reconstruction and upper-extremity lymphedema or breast cancer-related lymphedema. Our primary outcome was lymphedema occurrence. We performed a meta-analysis using random effects due to heterogeneity of the studies. Our search strategy identified 934 articles. After screening, 19 studies were included in our meta-analysis evaluating outcomes based on number of patients (7501) or number of breasts surgically treated (2063). Breast reconstruction was significantly associated with lower odds of lymphedema (p < 0.001) compared to mastectomy only or breast-conserving surgery. Lymphedema ra...Continue Reading

Citations

Nov 27, 2019·Journal of Plastic Surgery and Hand Surgery·Charalampos SiotosOluseyi Aliu
May 23, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sarah A McLaughlinAlphonse Taghian
Dec 29, 2020·Plastic and Reconstructive Surgery·Edward I Chang
Mar 6, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nalee KimSei Kyung Lee
Dec 22, 2020·Annals of Plastic Surgery·Arvind U GowdaTomer Avraham

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