Abstract
Atypical lesions such as atypical ductal hyperplasia (ADH) and lobular neoplasia are nonmalignant lesions that are associated with significant increased risk of developing breast cancer. Atypical lesions have been reported to present with focal increased radiotracer uptake on breast-specific gamma imaging (BSGI) examination, a novel physiologic tool for the detection of breast cancer. To date the sensitivity of BSGI in the detection of atypical lesions has not been reported. The purpose of this study is to determine the sensitivity of BSGI in detecting ADH and lobular neoplasia. A total of 1316 patients who received a BSGI exam between January 2006 and July 2009 were retrospectively reviewed. All patients who underwent minimally invasive biopsy and subsequent surgical excision where the highest pathology was solely ADH or lobular neoplasia (reported as ALH, lobular carcinoma in situ or lobular neoplasia), according to the pathology database were included (n = 15). The sensitivity was determined as the percentage of positive BSGI exams out of all patients diagnosed with ADH or lobular neoplasia who received a BSGI. Patient ages ranged from 39 to 67 (mean, 52). Eight of 15 patients had ADH, 6/15 lobular neoplasia, and 1/15 ADH an...Continue Reading
References
Jun 1, 1985·Cancer·D L PageM S Rados
Aug 3, 1999·AJR. American Journal of Roentgenology·L LibermanD D Dershaw
Nov 17, 2001·JAMA : the Journal of the American Medical Association·M C KingUNKNOWN National Surgical Adjuvant Breast and Bowel Project
Jul 31, 2002·Radiology·Roger J JackmanDebra M Ikeda
Jan 18, 2003·Lancet·David L PageJean F Simpson
Apr 28, 2004·Cancer·Julia TchouMonica Morrow
Apr 22, 2005·Histopathology·S SharmaC Sarkar
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David L Page, Jean F Simpson
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul J ChubaAmr Aref
Aug 30, 2005·Radiology·Rachel F BremBenjamin L Welch
Jul 22, 2006·Advances in Anatomic Pathology·Melinda F Lerwill
Jul 31, 2007·Academic Radiology·Rachel F BremJocelyn A Rapelyea
Sep 1, 2007·The Breast Journal·Rachel F BremTricia Kelly
Jan 24, 2008·Breast Cancer Research and Treatment·Andrew R GreenIan O Ellis
Feb 22, 2008·AJR. American Journal of Roentgenology·Rachel F BremShane Wasden
May 20, 2008·Radiology·Rachel F BremVivek Mathur
Oct 7, 2008·Der Pathologe·F A Tavassoli
Jan 22, 2009·AJR. American Journal of Roentgenology·Rachel F BremLillian H Stern
Feb 3, 2009·American Journal of Surgery·Minhao ZhouKari Steinbock
May 12, 2010·Academic Radiology·Rachel F BremJessica Torrente
Aug 26, 2010·Radiology·R Edward Hendrick
Nov 4, 2010·Radiology·Deborah J RhodesMichael K O'Connor
Feb 10, 2011·Medical Physics·Michael K O'ConnorRichard J Vetter
Citations
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Yu SunJian-Lun Liu
Jan 29, 2016·Cell & Bioscience·Sidney W FuRachel F Brem
Dec 15, 2015·The Breast Journal·Karin J KuhnRachel F Brem
Apr 14, 2016·Annals of Surgical Treatment and Research·Min Jeng ChoMi Young Kim
Jan 13, 2018·AJR. American Journal of Roentgenology·Rachel F BremChristel D Velasco
Sep 13, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rachel F Brem
Nov 19, 2020·BioMed Research International·Xinhong LiuXin Zhao
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wendie A Berg