Breast-specific gamma imaging in the detection of atypical ductal hyperplasia and lobular neoplasia

Academic Radiology
Caroline M LingRachel F Brem

Abstract

Atypical lesions such as atypical ductal hyperplasia (ADH) and lobular neoplasia are nonmalignant lesions that are associated with significant increased risk of developing breast cancer. Atypical lesions have been reported to present with focal increased radiotracer uptake on breast-specific gamma imaging (BSGI) examination, a novel physiologic tool for the detection of breast cancer. To date the sensitivity of BSGI in the detection of atypical lesions has not been reported. The purpose of this study is to determine the sensitivity of BSGI in detecting ADH and lobular neoplasia. A total of 1316 patients who received a BSGI exam between January 2006 and July 2009 were retrospectively reviewed. All patients who underwent minimally invasive biopsy and subsequent surgical excision where the highest pathology was solely ADH or lobular neoplasia (reported as ALH, lobular carcinoma in situ or lobular neoplasia), according to the pathology database were included (n = 15). The sensitivity was determined as the percentage of positive BSGI exams out of all patients diagnosed with ADH or lobular neoplasia who received a BSGI. Patient ages ranged from 39 to 67 (mean, 52). Eight of 15 patients had ADH, 6/15 lobular neoplasia, and 1/15 ADH an...Continue Reading

References

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Citations

Jan 29, 2016·Cell & Bioscience·Sidney W FuRachel F Brem
Jan 13, 2018·AJR. American Journal of Roentgenology·Rachel F BremChristel D Velasco
Sep 13, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Rachel F Brem
Nov 19, 2020·BioMed Research International·Xinhong LiuXin Zhao
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wendie A Berg

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