Breast tissue stiffness estimation for surgical guidance using gravity-induced excitation

Physics in Medicine and Biology
Rebekah H GriesenauerMichael I Miga

Abstract

Tissue stiffness interrogation is fundamental in breast cancer diagnosis and treatment. Furthermore, biomechanical models for predicting breast deformations have been created for several breast cancer applications. Within these applications, constitutive mechanical properties must be defined and the accuracy of this estimation directly impacts the overall performance of the model. In this study, we present an image-derived computational framework to obtain quantitative, patient specific stiffness properties for application in image-guided breast cancer surgery and interventions. The method uses two MR acquisitions of the breast in different supine gravity-loaded configurations to fit mechanical properties to a biomechanical breast model. A reproducibility assessment of the method was performed in a test-retest study using healthy volunteers and was further characterized in simulation. In five human data sets, the within subject coefficient of variation ranged from 10.7% to 27% and the intraclass correlation coefficient ranged from 0.91-0.944 for assessment of fibroglandular and adipose tissue stiffness. In simulation, fibroglandular content and deformation magnitude were shown to have significant effects on the shape and convex...Continue Reading

References

Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A Abi-DarghamM Laruelle
Jun 28, 2000·Physics in Medicine and Biology·R SinkusD Holz
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R V ParseyM Laruelle
Jul 9, 2002·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·J LorenzenG Adam
Mar 13, 2003·Physics in Medicine and Biology·Michael I Miga
Jun 30, 2005·Medical Physics·Michael I MigaJao J Ou
Nov 8, 2005·Medical Engineering & Physics·Timothy J CarterDavid J Hawkes
Jan 11, 2007·Biomechanics and Modeling in Mechanobiology·J H ChungM P Nash
Aug 31, 2007·Journal of Biomechanics·Jae-Hoon ChungMartyn P Nash
Feb 29, 2008·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J W Bartlett, C Frost
Mar 11, 2008·Medical Engineering & Physics·A Pérez del PalomarM Doblaré
Nov 11, 2008·Academic Radiology·Vijay RajagopalPoul M F Nielsen
Oct 1, 2008·Presence : Teleoperators and Virtual Environments·Sarthak MisraAllison M Okamura
Jun 22, 2011·IEEE Transactions on Bio-medical Engineering·Thomas S PheifferMichael I Miga
May 15, 2012·European Journal of Radiology·Bin ZhengDavid Gur
May 31, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Richard G Barr, Zheng Zhang
Nov 20, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Firat KaraA Alia
Oct 18, 2013·IEEE Journal of Biomedical and Health Informatics·Joachim GeorgiiRüdiger Westermann
Jan 31, 2014·Cancer Causes & Control : CCC·S HennesseyN F Boyd
Jun 21, 2015·International Journal of Computer Assisted Radiology and Surgery·Rebekah H ConleyMichael I Miga
Nov 19, 2015·Annals of Biomedical Engineering·Björn EibenDavid J Hawkes
Feb 11, 2016·Biomechanics and Modeling in Mechanobiology·Nilza G RamiãoDiana C Santos

❮ Previous
Next ❯

Citations

Aug 14, 2019·Journal of Biomedical Materials Research. Part a·Xiang-Zhen YanFang Yang
Oct 28, 2019·Journal of Biomedical Materials Research. Part a·Archana Singh, Prakriti Tayalia
Dec 3, 2020·Genes & Development·Minhong Shen, Yibin Kang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.