Breast tumor copy number aberration phenotypes and genomic instability.

BMC Cancer
Jane FridlyandDonna G Albertson

Abstract

Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes. We applied array comparative genomic hybridization (CGH) to the analysis of breast tumors. The variation in the levels of genomic instability amongst tumors prompted us to investigate whether alterations in processes/genes involved in maintenance and/or manipulation of the genome were associated with particular types of genomic instability. We discriminated three breast tumor subtypes based on genomic DNA copy number alterations. The subtypes varied with respect to level of genomic instability. We find that shorter telomeres and altered telomere related gene expression are associated with amplification, implicating telomere attrition as a promoter of this type of aberration in breast cancer. On the other hand, the numbers of chromosomal alterations, particularly low level changes, are associated with alt...Continue Reading

Associated Datasets

References

Apr 1, 1998·Nature·D P CahillB Vogelstein
Oct 8, 1999·Trends in Cell Biology·J R Bischoff, G D Plowman
Nov 1, 2001·Nature Genetics·A M SnijdersD G Albertson
Nov 27, 2001·Science·D CortezS J Elledge
Jan 19, 2002·Genes & Development·Bing RenBrian David Dynlacht
May 15, 2002·Human Mutation·Magali OlivierPierre Hainaut
Jan 16, 2003·Oncogene·Eli Berkovich, Doron Ginsberg
Apr 4, 2003·Genes & Development·Xin WangLei Li
Jul 11, 2003·Oncogene·Antoine M SnijdersDonna G Albertson
Aug 2, 2003·Nature Reviews. Cancer·David M FeldserCarol W Greider
Aug 19, 2003·The Journal of Biological Chemistry·Richard VernellHeiko Müller
Aug 19, 2003·Nature Genetics·Donna G AlbertsonJoe W Gray
Feb 14, 2004·Bioinformatics·Tim Beissbarth, Terence P Speed
Apr 16, 2004·The Journal of Biological Chemistry·Michael MarkeyErik S Knudsen
May 6, 2004·Cancer Research·Zhenghe WangChristoph Lengauer
May 13, 2004·Human Molecular Genetics·Pamela L ParisHerman van Dekken
Jun 29, 2004·The Journal of Pathology·Emad A RakhaIan O Ellis
Jul 24, 2004·The Journal of Biological Chemistry·Yuying JiangRachel A Altura
Jul 29, 2004·Cancer Biology & Therapy·Ralph ScullyGanesh Nagaraju
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Rui-Hong WangChu-Xia Deng
Apr 15, 2005·Nature·Vassilis G GorgoulisThanos D Halazonetis
Sep 28, 2005·Oncogene·M T Pickering, T F Kowalik
Oct 26, 2005·Nature Cell Biology·Robert HabedanckErich A Nigg
Nov 11, 2005·Breast Cancer Research : BCR·Tom van WezelAnne-Marie Cleton-Jansen
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia FeldnerCatherina G Becker

❮ Previous
Next ❯

Citations

Dec 5, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Silke LassmannMartin Werner
Apr 5, 2013·Human Genetics·Lorenzo Melchor, Javier Benítez
Jun 26, 2007·Breast Cancer Research and Treatment·Kristin N ByrdDonna G Albertson
Feb 23, 2008·Breast Cancer Research and Treatment·Mads ThomassenTorben A Kruse
Jul 9, 2010·Breast Cancer Research and Treatment·Simon A JoossePetra M Nederlof
Jan 26, 2011·Breast Cancer Research and Treatment·Lenora W M LooPeggy L Porter
Oct 30, 2012·Breast Cancer Research and Treatment·Anguraj SadanandamChristopher C Benz
Nov 18, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Angels Sierra
Apr 30, 2013·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Maki FukamiShinzaburo Noguchi
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cathy B MoelansPaul J van Diest
Jun 3, 2008·Nature Cell Biology·Darren J BakerJan M van Deursen
Jun 28, 2008·Nature Genetics·Jorge S Reis-FilhoMitch Dowsett
Aug 31, 2006·Nature Genetics·Jonathan R Pollack
Oct 23, 2009·Bioinformatics·Bart P P van Houte, Jaap Heringa
Dec 25, 2007·Biostatistics·Wessel N Van WieringenBauke Ylstra
Jun 19, 2009·Carcinogenesis·Yun-Ling ZhengSahar M Selim
Oct 2, 2007·Current Opinion in Oncology·Isabelle Vanden BemptChristiane De Wolf-Peeters
Dec 3, 2008·The American Journal of Surgical Pathology·Sandra J ShinPaul Peter Rosen
Aug 25, 2009·The American Journal of Surgical Pathology·Yunn-Yi ChenFrederic M Waldman
Nov 5, 2010·Cold Spring Harbor Perspectives in Biology·Charles M Perou, Anne-Lise Børresen-Dale
Jul 2, 2010·Science Translational Medicine·Hege G RussnesAnne-Lise Børresen-Dale
Aug 24, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J ClimentJ Perez-Losada
May 28, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roshan AgarwalBryan T Hennessy
Nov 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aditi BhattacharyaDonna G Albertson
Jun 23, 2010·BMC Bioinformatics·Ilari ScheininBauke Ylstra
Nov 1, 2007·BMC Bioinformatics·Carmen LaiMarcel J T Reinders
Oct 24, 2007·BMC Genomics·Johan StaafJohan Vallon-Christersson
Dec 7, 2006·BMC Cancer·Ruria NambaJeffrey P Gregg
Oct 9, 2008·BMC Cancer·Susanna L CookePaul A W Edwards

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
dissection

Software Mentioned

GOStats
Quantity One

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

© 2022 Meta ULC. All rights reserved