Abstract
The breast tumor resembling the tall cell variant of papillary thyroid carcinoma is a very unusual mammary carcinoma whose histologic and predominant nuclear features mimic a papillary thyroid carcinoma. We report the case of a 64-year-old woman who presented with a palpable nodule in the right breast. Fine needle aspiration disclosed abundant cellularity with isolated cells, sheets, and papillary formations of epithelial cells with nuclear grooves. Histologically, the neoplastic cells were arranged in a solid to papillary architecture, with follicular-like and cribriform areas. The cells were columnar to cuboidal with eosinophilic cytoplasm, clear chromatin, nuclear grooves, and occasional nuclear pseudoinclusions. Tumor cells were positive for cytokeratins, alpha and beta-estrogen receptors, progesterone receptor, androgen receptor, CEA, and bcl-2. We searched for BRAF mutations with negative results. Recognizing the cytologic and histologic characteristics of these peculiar mammary tumors that mimic thyroid carcinomas can avoid unnecessary clinical investigations.
References
Apr 11, 2001·American Journal of Clinical Pathology·J Cameselle-TeijeiroM Sobrinho-Simoes
May 23, 2002·The European Journal of Surgery = Acta Chirurgica·Elisabeth M Chávez-UribeJosé L Puente-Dominguez
Dec 11, 2002·The Journal of Pathology·Bing XuToshiaki Sano
Jul 26, 2003·Oncogene·Paula SoaresManuel Sobrinho-Simões
Jul 29, 2003·The American Journal of Surgical Pathology·V EusebiJ Rosai
Aug 26, 2003·The American Journal of Pathology·Andrew H FischerSissy M Jhiang
Jan 27, 2004·The Journal of Pathology·Vítor TroviscoManuel Sobrinho-Simões
Jun 30, 2004·The American Journal of Surgical Pathology·Vincenzo EusebiJuan Rosai
Aug 13, 2004·International Journal of Surgical Pathology·W Cheuk, John K C Chan
Feb 1, 2005·Endocrine Pathology·S RezkA Khan
May 20, 2005·Virchows Archiv : an International Journal of Pathology·Vítor TroviscoManuel Sobrinho-Simões
Citations
Jun 23, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar HameedJohn D Pfeifer
Nov 9, 2010·Thyroid : Official Journal of the American Thyroid Association·Amanda WintersEmad Kandil
Jul 15, 2009·The Breast Journal·Sing Yun ChangAtilla Omeroglu
Jun 22, 2010·Journal of Cellular Biochemistry·Andrew H FischerPeter Kulesza
Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Mehdi AgoumiMalcolm M Hayes
Apr 19, 2017·The American Journal of Surgical Pathology·Maria P FoschiniJuan Rosai
Dec 19, 2006·International Journal of Surgical Pathology·Anna L TosiMaria P Foschini
Apr 1, 2018·Histopathology·John R LozadaFelipe C Geyer
Sep 20, 2018·International Journal of Surgical Pathology·Elaine ZhongSyed A Hoda
Dec 17, 2010·Diagnostic Cytopathology·Dilip K DasAbdulla I F Behbehani
Feb 9, 2012·Advances in Anatomic Pathology·Shahla MasoodMelanie J Kubik
Jun 1, 2020·Molecular Biology Reports·Simon HaefligerTatjana Vlajnic
Jan 4, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fresia ParejaEdi Brogi
May 29, 2014·International Journal of Surgical Pathology·Renato ColellaGuido Bellezza
May 23, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nadjla AlsadounLaurent Arnould
Jun 21, 2020·Surgical Case Reports·Xue LinMasakazu Toi
Apr 5, 2017·American Journal of Clinical Pathology·Rohit BhargavaMarina Nikiforova
May 6, 2020·The Breast Journal·Kristen E Muller, Jonathan D Marotti
Oct 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fresia ParejaJorge S Reis-Filho
Jan 20, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Timothy Kwang Yong Tay, Puay Hoon Tan
Feb 3, 2021·The Breast Journal·Helen J TrihiaIoannis Provatas
Nov 29, 2017·Pathology·Emad A Rakha, Ian O Ellis
Jul 23, 2021·Virchows Archiv : an International Journal of Pathology·Stuart J SchnittThomas Decker
Aug 31, 2021·Virchows Archiv : an International Journal of Pathology·L CimaM P Foschini