PMID: 16501842Feb 28, 2006Paper

Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: a case report

International Journal of Surgical Pathology
J Cameselle-TeijeiroM Sobrinho-Simoes

Abstract

The breast tumor resembling the tall cell variant of papillary thyroid carcinoma is a very unusual mammary carcinoma whose histologic and predominant nuclear features mimic a papillary thyroid carcinoma. We report the case of a 64-year-old woman who presented with a palpable nodule in the right breast. Fine needle aspiration disclosed abundant cellularity with isolated cells, sheets, and papillary formations of epithelial cells with nuclear grooves. Histologically, the neoplastic cells were arranged in a solid to papillary architecture, with follicular-like and cribriform areas. The cells were columnar to cuboidal with eosinophilic cytoplasm, clear chromatin, nuclear grooves, and occasional nuclear pseudoinclusions. Tumor cells were positive for cytokeratins, alpha and beta-estrogen receptors, progesterone receptor, androgen receptor, CEA, and bcl-2. We searched for BRAF mutations with negative results. Recognizing the cytologic and histologic characteristics of these peculiar mammary tumors that mimic thyroid carcinomas can avoid unnecessary clinical investigations.

References

Apr 11, 2001·American Journal of Clinical Pathology·J Cameselle-TeijeiroM Sobrinho-Simoes
May 23, 2002·The European Journal of Surgery = Acta Chirurgica·Elisabeth M Chávez-UribeJosé L Puente-Dominguez
Jul 29, 2003·The American Journal of Surgical Pathology·V EusebiJ Rosai
Aug 26, 2003·The American Journal of Pathology·Andrew H FischerSissy M Jhiang
Jan 27, 2004·The Journal of Pathology·Vítor TroviscoManuel Sobrinho-Simões
Jun 30, 2004·The American Journal of Surgical Pathology·Vincenzo EusebiJuan Rosai
May 20, 2005·Virchows Archiv : an International Journal of Pathology·Vítor TroviscoManuel Sobrinho-Simões

❮ Previous
Next ❯

Citations

Jun 23, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar HameedJohn D Pfeifer
Nov 9, 2010·Thyroid : Official Journal of the American Thyroid Association·Amanda WintersEmad Kandil
Jul 15, 2009·The Breast Journal·Sing Yun ChangAtilla Omeroglu
Jun 22, 2010·Journal of Cellular Biochemistry·Andrew H FischerPeter Kulesza
Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Mehdi AgoumiMalcolm M Hayes
Jan 4, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fresia ParejaEdi Brogi
May 29, 2014·International Journal of Surgical Pathology·Renato ColellaGuido Bellezza
May 6, 2020·The Breast Journal·Kristen E Muller, Jonathan D Marotti
Oct 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Fresia ParejaJorge S Reis-Filho
Jan 20, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Timothy Kwang Yong Tay, Puay Hoon Tan
Nov 29, 2017·Pathology·Emad A Rakha, Ian O Ellis
Jul 23, 2021·Virchows Archiv : an International Journal of Pathology·Stuart J SchnittThomas Decker
Aug 31, 2021·Virchows Archiv : an International Journal of Pathology·L CimaM P Foschini

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.