Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis

Pediatric Neurology
J Nicholas BrentonMyla D Goldman

Abstract

Risk of multiple sclerosis (MS) is influenced by environment and genetics. Infant breastfeeding appears protective against some childhood autoimmune disorders, but its impact on risk of MS in childhood is unknown. The objective of this study is to analyze the association of breastfeeding in infancy on future risk of pediatric-onset MS. Biological mothers of 36 consecutive pediatric-onset MS patients completed a questionnaire on history of breastfeeding and various birth and demographic factors. The control group consisted of 72 otherwise healthy patients with a diagnosis of migraine and normal brain magnetic resonance imaging obtained less than 12 months before enrollment. Inverse probability of treatment weighting was used to reduce selection bias and balance the covariates between breastfed and non-breastfed children. Demographics (with the exception of body mass index) and birth factors were not significantly different between groups. Whereas 36% of cases were breastfed, 71% of controls were breastfed (P = 0.001). The median duration of breastfeeding was 0 weeks (range: 0 to 40 weeks) for cases and 16 weeks (range: 0 to 216 weeks) for controls. Lack of infant breastfeeding was associated with future diagnosis of pediatric-on...Continue Reading

Citations

Apr 10, 2018·Current Opinion in Neurology·Kevin Rostásy, Barbara Bajer-Kornek
Feb 23, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Emilio Portaccio, Maria Pia Amato
Oct 16, 2018·Frontiers in Pediatrics·Peter S Hsu, Ralph Nanan
Jun 19, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Philip O Anderson
Jul 31, 2020·Multiple Sclerosis Journal - Experimental, Translational and Clinical·A K HedströmL Alfredsson
Feb 14, 2021·Multiple Sclerosis and Related Disorders·Nuha M AlkhawajahSalman Aljarallah
May 18, 2021·International Journal of Epidemiology·Elisa BaldinMaura Pugliatti
Jun 10, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Viktor GrutPeter Sundström

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