PMID: 2492749Feb 1, 1989Paper

Breath hydrogen excretion as a screening test for the early diagnosis of necrotizing enterocolitis

American Journal of Diseases of Children
H W CheuM I Rowe

Abstract

We measured breath H2 excretion in 122 neonates from birth to 1 month of age. The patients weighed less than 2000 g at birth and thus were at risk for developing necrotizing enterocolitis (NEC). Hydrogen excretion was normalized for the quality of the expired air by dividing by the carbon dioxide pressure of the gas sample. The mean (+/- SD) peak H2/CO2 ratio was significantly different between the seven patients who subsequently developed NEC (9.4 +/- 2.7 ppm/mm Hg) and the 115 patients who did not (5.0 +/- 3.5 ppm/mm Hg). The prevalence of NEC was 5.7% in the present study. Defining a positive test as one with a ratio value of greater than or equal to 8.0 ppm/mm Hg, the resulting screening test had a sensitivity of 86% and a specificity of 90%. The screening test yielded a 33% predictive value of a positive test and a 99% predictive value of a negative test. High H2 excretion occurred eight to 28 hours before the earliest clinical signs of NEC. Breath H2 excretion is a simple noninvasive test that may be useful in the management of the premature neonate at risk for the development of NEC.

Citations

Aug 26, 2003·Archives of Disease in Childhood. Fetal and Neonatal Edition·M MillarK Costeloe
Jul 20, 2004·Clinical Microbiology Reviews·David Kaufman, Karen D Fairchild
Feb 5, 2009·Pediatric Research·Christopher YoungJosef Neu
Feb 19, 2013·Clinics in Perinatology·James E Moore
Sep 24, 2015·Pediatric Surgery International·Paul FlemingSimon Eaton
Jan 18, 2014·The Journal of Pediatrics·Karl G SylvesterR Lawrence Moss
Mar 1, 2016·Early Human Development·Simon EatonNigel J Hall
Sep 26, 2014·World Journal of Clinical Pediatrics·Xiao-Zhong HuangJing Lin
Dec 8, 2019·Experimental Biology and Medicine·Alissa L MeisterR Alberto Travagli
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Jing LinMark W Babyatsky
May 20, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·O SzylitJ C Borderon
Aug 2, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Bhawan Deep GargAnju Bansal

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