Abstract
Oxidative stress (OS) is well documented in asthma, but so far, little data has been reported in nonasthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant asthma (SAR+A), using breath markers in exhaled air and in Exhaled Breath Condensate (EBC). In addition, the effects of natural allergen exposure and intranasal steroid treatment on these markers were evaluated. Exhaled NO (eNO) and CO, combined with measurements of 8-Isoprostane (Iso-8), Leukotriene B4 (LTB4) and nitrate/nitrite in EBC, were performed in 23 patients, 11 with SAR and 12 with SAR+A, and 16 healthy subjects. Iso-8 and LTB4 were significantly increased in both groups of patients (median values 43.6 pg/ ml and 138.4 pg/ml in SAR group; 38.9 pg/ml, and 164.6 pg/ml in SAR+A group respectively; p>0.05) compared to healthy subjects (18.6 pg/ml and 7.8 pg/ml; p<0.05). Nitrate/nitrite and eNO levels were elevated in both groups compared to controls, but were significantly higher in the SAR+A compared to SAR group (nitrate/nitrite 9 microM and 3.9 microM; p=0.025; and eNO 18.5 ppb and 12.5 ppb, respectively; p>0.05). Nasal steroids cause...Continue Reading
References
Feb 1, 1992·The American Review of Respiratory Disease·W J CalhounC A Stevens
Jul 1, 1997·The Journal of Allergy and Clinical Immunology·A ForesiD Olivieri
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·J E RepineI Lankhorst
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·K ZayasuH Sasaki
Mar 1, 1997·Progress in Lipid Research·J D Morrow, L J Roberts
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M MonmaH Sasaki
Nov 26, 1999·The European Respiratory Journal·C GratziouC Roussos
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C GratziouC Roussos
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·S A Kharitonov, P J Barnes
Sep 4, 2001·Respiratory Medicine·K GanasN Kalogeropoulos
Nov 8, 2001·European Journal of Pharmacology·G FolkertsF P Nijkamp
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·S B KhatriS C Erzurum
Apr 10, 2002·The Journal of Allergy and Clinical Immunology·Paolo Montuschi, Peter J Barnes
Jul 12, 2002·The Journal of Allergy and Clinical Immunology·John Hunt
Sep 5, 2002·The Journal of Allergy and Clinical Immunology·Russell P Bowler, James D Crapo
Oct 3, 2002·Allergy·A LinnebergUNKNOWN Copenhagen Allergy Study
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Zsuzsanna CsomaPeter J Barnes
Feb 18, 2003·The Journal of Allergy and Clinical Immunology·Alessandra SandriniKenneth R Chapman
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L F JouavilleD Caillaud
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·Stefania ZanconatoEugenio Baraldi
Jan 14, 2005·Allergy·P CápM Malý
Apr 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN European Respiratory Society
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FaillaN Crimi
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Marco FaillaCarlo Vancheri
Citations
Mar 9, 2011·Journal of Breath Research·Réka Gajdócsy, Ildikó Horváth
Jun 13, 2013·Current Opinion in Allergy and Clinical Immunology·Jonathan A Bernstein
Nov 28, 2013·American Journal of Rhinology & Allergy·Jonathan A Bernstein
Jun 20, 2014·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Milos JesenakEva Babusikova
Jan 20, 2017·Journal of Breath Research·Adam M PeelYoon K Loke
Aug 15, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Fahad M AldakheelAdrian J Lowe
Mar 13, 2020·Archives of Dermatological Research·Gulin KaracanOzcan Erel
Jun 3, 2020·International Journal of Molecular Sciences·Yara ShomanIrina Guseva Canu
Mar 23, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Melda CelikOmer Kalayci
Jul 31, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Roberta PisiAlfredo Chetta
Oct 22, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Sachio TakenoKatsuhiro Hirakawa
Dec 30, 2014·Current Opinion in Allergy and Clinical Immunology·Koa HosokiSanjiv Sur
Aug 10, 2016·Oxidative Medicine and Cellular Longevity·Sara MantiCarmelo Salpietro
Jun 19, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S G KhooL P McGarvey
Jun 19, 2015·American Journal of Respiratory Cell and Molecular Biology·Koa HosokiSanjiv Sur
May 25, 2016·American Journal of Rhinology & Allergy·Seckin UlusoyOzcan Erel
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Nicholas D ManzoJanice A Dye
Dec 15, 2010·International Journal of Molecular Sciences·Monika JanickaJacek Namieśnik
Feb 12, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Arzu Didem YalcinReginald M Gorczynski
Jan 23, 2010·Clinical Reviews in Allergy & Immunology·Yu ShaoqingLi Genhong
Nov 26, 2009·Current Opinion in Allergy and Clinical Immunology·Melinda Braskett, Marc A Riedl
Jul 22, 2020·Ear, Nose, & Throat Journal·Ayse E GökerYavuz Uyar
Jan 1, 2011·Clinical and Translational Allergy·Daniela LinharesJoão A Fonseca
Oct 13, 2020·The World Allergy Organization Journal·Philip W RouadiJean Bousquet
May 28, 2019·Respiratory Medicine·Mauro ManiscalcoGiovanna Elisiana Carpagnano
Sep 25, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tatsuro NakamuraTakahisa Murata
Dec 23, 2009·Current Opinion in Allergy and Clinical Immunology