Breath pentane excretion as a marker of disease activity in rheumatoid arthritis

Free Radical Research Communications
S HumadJ Skosey

Abstract

Activated inflammatory cells are capable of stimulating lipid peroxidation. In 27 patients with rheumatoid arthritis, we measured the pulmonary excretion of pentane, a product released during lipid peroxidation. We found highly significant correlations between pentane excretion and both joint inflammation (r = 0.88, p less than 0.001) and the erythrocyte sedimentation rate (r = 0.80, p less than 0.001). Patients treated with gold compounds or D-penicillamine excreted diminished amounts of pentane. The data suggest that lipid peroxidation may be related in part to the mechanism of injury in rheumatoid arthritis.

References

Jan 1, 1979·Clinical Science·J Lunec, T L Dormandy
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
Jan 19, 1984·Nature·M SuthanthiranK H Stenzel

❮ Previous
Next ❯

Citations

Feb 1, 1992·Neurochemical Research·P K Toshniwal, E J Zarling
Jun 1, 1993·Diseases of the Colon and Rectum·J KokoszkaH Abcarian
Apr 22, 1999·Diseases of the Colon and Rectum·M A PelliG Bassotti
Feb 1, 1993·Mechanisms of Ageing and Development·E J ZarlingS Kamath
Nov 6, 1993·Lancet·R Howard
Jan 1, 1991·Free Radical Biology & Medicine·K N Jeejeebhoy
Aug 1, 1994·Free Radical Biology & Medicine·C M KneepkensC C Roy
Jan 1, 1996·Free Radical Biology & Medicine·O I Aruoma
Aug 18, 2000·Free Radical Biology & Medicine·E A Meagher, G A FitzGerald
Jan 16, 1999·Free Radical Biology & Medicine·L L de ZwartN P Vermeulen
Oct 22, 2002·Journal of Pharmacological and Toxicological Methods·François GaboriauJacques Philippe Moulinoux
Mar 26, 2004·Nature Reviews. Microbiology·Anthony P Turner, Naresh Magan
Jan 1, 1993·Nutrition and Cancer·K GottliebS Sugerman
Apr 26, 2003·Heart Disease·Michael PhillipsManuel Salazar
Dec 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·C M Harrison, C C Andersen
Nov 1, 1992·Annals of the Rheumatic Diseases·B HalliwellS Chirico
Jun 1, 1995·Annals of the Rheumatic Diseases·B Halliwell
Dec 1, 1996·Annals of the Rheumatic Diseases·H KaurB Halliwell
May 15, 2001·Annals of the Rheumatic Diseases·S BasuB Halliwell
Sep 1, 1993·Journal of Clinical Pathology·M PhillipsJ Greenberg
Oct 23, 2008·Occupational and Environmental Medicine·C-H PanK-Y Wu
Sep 11, 2012·Malaria Journal·Rina P M WongTimothy M E Davis
Feb 22, 2012·Sensors·Alphus D Wilson, Manuela Baietto
Aug 1, 1995·Free Radical Research·S MendisD E Euler
Jan 1, 1993·Free Radical Research Communications·A Cailleux, P Allain
May 1, 1994·Free Radical Research·M PhillipsM Sabas
Sep 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·O M Pitkänen
May 20, 2003·The Breast Journal·Michael PhillipsCynthia Wong
Jul 30, 2010·IEEE Transactions on Bio-medical Engineering·Dongmin GuoJianhua Yang
Feb 14, 2002·Rheumatic Diseases Clinics of North America·Maripat Corr, Gary S Firestein
May 29, 2004·American Journal of Obstetrics and Gynecology·Michael MorettiJoel Greenberg
Jun 1, 1992·Journal of the American College of Nutrition·E J ZarlingS Sugerman
Apr 13, 2004·The Veterinary Record·C A WyseS Love
May 1, 1996·European Journal of Anaesthesiology·J PincemailR Limet
Jan 26, 2017·Journal of Exposure Science & Environmental Epidemiology·Chih-Hong PanChing-Huang Lai
Sep 1, 2008·Journal of Breath Research·B P J de Lacy CostelloM Richards
May 29, 2000·Free Radical Research·M PhillipsR N Cataneo
May 18, 2017·Scientific Reports·Wang LiXititan Pi
Jul 20, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·M PhillipsR N Cataneo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.