Breath volatile organic compounds of lung transplant recipients with and without chronic lung allograft dysfunction

Journal of Breath Research
L KüppersJ M Hohlfeld

Abstract

Chronic lung allograft dysfunction with its clinical correlative of bronchiolitis obliterans syndrome (BOS) remains the major limiting factor for long-term graft survival. Currently there are no established methods for the early diagnosis or prediction of BOS. To assess the feasibility of breath collection as a non-invasive tool and the potential of breath volatile organic compounds (VOC) for the early detection of BOS, we compared the breath VOC composition between transplant patients without and different stages of BOS. 75 outpatients (25 BOS stage 0, 25 BOS stage 1 + 2, 25 BOS stage 3) after bilateral lung transplantation were included. Exclusion criteria were active smoking, oxygen therapy and acute infection. Patients inhaled room air through a VOC and sterile filter and exhaled into an aluminum reservoir tube. Breath was loaded directly onto Tenax® TA adsorption tubes and was subsequently analyzed by gas-chromatography/mass-spectrometry. The three groups were age and gender matched, but differed with respect to time since transplantation, the spectrum of underlying disease, and treatment regimes. Relative to patients without BOS, BOS stage 3 patients showed a larger number of different VOCs, and more pronounced difference...Continue Reading

References

Apr 22, 1999·Diseases of the Colon and Rectum·M A PelliG Bassotti
Nov 13, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S M StuderT H Risby
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Apr 26, 2003·Heart Disease·Michael PhillipsManuel Salazar
Jan 7, 2009·Therapeutic Advances in Respiratory Disease·Jens Gottlieb
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Gundeep S DhillonMark R Nicolls
May 29, 2010·American Journal of Respiratory and Critical Care Medicine·C Ashley Finlen CopelandScott M Palmer
Jul 9, 2010·Current Opinion in Organ Transplantation·Anil SeetharamT Mohanakumar
Feb 16, 2011·Biomedical Chromatography : BMC·Agnieszka UlanowskaBogusław Buszewski
Mar 1, 2009·Journal of Breath Research·Robert H Brown, Terence H Risby
Dec 1, 2008·Journal of Breath Research·Jonathan BeauchampArmin Hansel
Mar 16, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Geert M VerledenBart M Vanaudenaerde
Mar 23, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Masaaki SatoShaf Keshavjee
Apr 23, 2011·Clinics in Chest Medicine·Tereza MartinuScott M Palmer
Jul 20, 2011·Journal of Cardiothoracic Surgery·Don Hayes
Oct 4, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieMarshall I Hertz
May 5, 2012·Journal of Breath Research·Robin Michael Statham Thorn, John Greenman
May 25, 2012·Journal of Breath Research·Agnes W BootsFrederik J van Schooten
Sep 29, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Efrat OfekDavid M Hwang
Feb 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M GreerT Fuehner
Mar 1, 2013·Journal of Breath Research·Dorottya KovacsIldiko Horvath
May 11, 2013·Journal of Chromatographic Science·Emma TaitJohn R Dean
Jul 5, 2013·Clinical Microbiology Reviews·Shneh SethiTrinad Chakraborty
Jan 1, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Geert M VerledenPaul Corris
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe
Apr 4, 2014·PloS One·Hannah GaimsterDavid K Summers
Apr 29, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Paweł MochalskiAnton Amann
May 9, 2014·The New England Journal of Medicine·Alan F BarkerMarshall I Hertz
Jul 1, 2014·Human Immunology·Adam S A Gracon, David S Wilkes
Sep 3, 2014·Trends in Biotechnology·Nicholas J W RattrayStephen J Fowler
Nov 2, 2014·The European Respiratory Journal·Keith C MeyerUNKNOWN ISHLT/ATS/ERS BOS Task Force Committee
Feb 18, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sameem AbedinDaniel R Couriel
Apr 12, 2015·Free Radical Biology & Medicine·M E DolchG Schelling
May 6, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S E VerledenA Haverich
Oct 7, 2015·Trends in Microbiology·Jin-Hyung LeeJintae Lee
Oct 27, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Don HayesBryan A Whitson
Feb 2, 2016·Journal of Breath Research·Florence N SchleichFrederik J Van Schooten
Mar 2, 2016·Archives of Pathology & Laboratory Medicine·Aliya N Husain, Edward R Garrity
May 26, 2016·Current Infectious Disease Reports·Aric L Gregson
May 17, 2017·World Journal of Transplantation·Kelly E HathornWai-Kit Lo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Denis Hadjiliadis, Michael A Hutcheon
American Journal of Respiratory and Critical Care Medicine
Alain Van MuylemMarc Estenne
American Journal of Respiratory and Critical Care Medicine
C Ashley Finlen CopelandScott M Palmer
© 2022 Meta ULC. All rights reserved