Breath volatolomics for diagnosing chronic rhinosinusitis

International Journal of Nanomedicine
Yoav Y BrozaHossam Haick

Abstract

Chronic rhinosinusitis (CRS) is one of the most common chronic diseases treated by primary care physicians. It is increasingly recognized that CRS and nasal polyposis (NP) comprise several disease processes with diverse causes. Hence, subgroups of sinusitis need to be differentiated so that patients can be screened appropriately and personalized medical treatment provided. To address this need, we use a cross-reactive nanoarray based on either molecularly modified gold nanoparticles or molecularly modified single-walled carbon nanotubes, combined with pattern recognition for analyzing breath samples. Breath samples were collected from three groups of volunteers (total 71) at the Hillel Yaffe Medical Center: CRS, NP, and control. Nanoarray results discriminated between patients with sinusitis and the control group with 87% sensitivity, 83% specificity, and 85% accuracy. The system also discriminated well between the subpopulations: 1) CRS vs control (76% sensitivity, 90% specificity); 2) CRS vs NP (82% sensitivity, 71% specificity); and 3) NP vs control (71% sensitivity, 90% specificity). This preliminary study shows that a nanoarray-based breath test for screening population for sinusitis-related conditions is feasible.

Citations

May 28, 2020·Cancer Communications·Alaa GharraHossam Haick
Jul 2, 2019·The British Journal of Surgery·Y Y BrozaH Haick
Jun 28, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Dina Hashoul, Hossam Haick
Dec 2, 2020·Journal of Personalized Medicine·Michał MichalikMichał J Markuszewski
Jan 3, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ting ChenQianming Chen
Feb 14, 2021·Pharmaceutics·Junhu TaiTae Hoon Kim

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Methods Mentioned

BETA
feature extraction

Clinical Trials Mentioned

NCT03379701

Software Mentioned

JMP

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