Breathing during wakefulness and sleep after human heart-lung transplantation

The American Review of Respiratory Disease
M H SandersR L Hardesty

Abstract

To study the effects of pulmonary denervation on breathing during sleep, sleep studies were conducted on seven heart-lung transplant recipients (H-LT) and a comparable number of sex-matched normal subjects of similar age. Four of the H-LT patients had a restrictive pattern on spirometry. The time since transplantation ranged from 45 to 1,102 days. There were no significant differences between the groups with respect to total sleep time or distribution of sleep stages. There were no significant differences between the H-LT recipients and normal subjects with respect to baseline awake oxyhemoglobin saturation (SaO2) or the nadirs of SaO2 during REM and non-REM sleep, the absolute number and frequency (number per hour of sleep) of apneas, hypopneas, desaturation events, both over the whole night of study or separately during non-REM and REM sleep. Across wakefulness and all sleep stages, the H-LT patients tended to have shorter total respiratory cycle times (Ttot) (p = 0.052) and more rapid breathing frequency (F) than the normal subjects. This was associated with significantly shorter inspiratory times (Tl) (p less than 0.001) and smaller duty cycles (Tl/Ttot) (p less than 0.005) in the H-LT recipients. During non-REM and REM sle...Continue Reading

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Citations

Sep 18, 2012·American Journal of Respiratory and Critical Care Medicine·Don HayesTodd L Astor
Aug 27, 2014·Clinics in Chest Medicine·Paola Pierucci, Monique Malouf
Apr 30, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Monique A MaloufAllan R Glanville
Nov 16, 2004·Anesthesiology Clinics of North America·Mark T Keegan, David J Plevak
Nov 1, 1996·Journal of Applied Physiology·C TantucciC A Sorbini
Oct 17, 2002·Journal of Applied Physiology·Weiying ZhaoPaul W Davenport
Jul 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·F Lofaso

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