Breathing He-O2 increases ventilation but does not decrease the work of breathing during exercise

American Journal of Respiratory and Critical Care Medicine
Tony G Babb

Abstract

We previously observed an increase in minute ventilation (V E) with resistive unloading (He-O2 breathing) in healthy elderly subjects with normal pulmonary function. To investigate the effects of resistive unloading in elderly subjects with mild chronic airflow limitation (FEV(1)/FVC: 61 +/- 4%), we studied 10 elderly men and women 70 +/- 3 yr of age. These subjects performed graded cycle ergometry to exhaustion, once breathing room air and once breathing a He-O2 gas mixture (79% He, 21% O2). V E, pulmonary mechanics, and PET(CO2) were measured during each 1-min increment in work rate. Data were analyzed by paired t test at rest, at ventilatory threshold (VTh), and during maximal exercise. V E was significantly (p < 0.05) increased at VTh (3.4 +/- 4.0 L/min or 12 +/- 15% increase) and maximal exercise (15.2 +/- 9.7 L/min or 22 +/- 13% increase) while breathing He-O2. Concomitant to the increase in V E, PET(CO2) was decreased at all levels (p < 0.01), whereas total work of breathing against the lung was not different. We concluded that V E is increased during He-O2 breathing because of resistive unloading of the airways and the maintenance of the relationship between the work of breathing and exercise work rate.

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Citations

Aug 19, 2007·European Journal of Applied Physiology·Scott J ButcherStewart R Petersen
Oct 19, 2002·Respiratory Physiology & Neurobiology·T G Babb, Darren S DeLorey
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Oct 25, 2012·Pulmonary Medicine·Matteo Pecchiari
Jan 14, 2003·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN American College of Chest Physicians
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·Elizabeth A LaudePeter M Calverley
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