Breathing mode of conformational fluctuations in globular proteins.

International Journal of Peptide and Protein Research
Y Suezaki, N Go

Abstract

Globular proteins in the native state are assumed to behave as continuous elastic spheres in the low frequency breathing motions. Reasonable values of Young's modulus E = 10(11) dyne/cm2 and the radius of the sphere ro = 20 A, yield a wave number of 26 cm-1 for the fundamental vibration of the sphere. The peak at around 30 cm-1 in the laser Raman spectra of native alpha-chymotrypsin and pepsin observed by Brown et al. might be assigned to the breathing motion which the native proteins undergo as continuous elastic bodies.

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