PMID: 2105410Jan 1, 1990Paper

Breathing pattern affects respiratory heat loss but not bronchoconstrictor response in asthma

Lung
E P IngenitoJ Solway

Abstract

To determine whether changes in breathing pattern alone affect respiratory heat loss (RHL) and the constrictor response to cold dry gas hyperpnea in asthmatic subjects, we performed the following 2 part study: first we measured RHL in 8 asthmatic and 8 normal subjects during controlled eucapnic hyperpnea while they breathed at inspiratory to expiratory ratios (I/E) of 1:3, 3:1, and 2:2, and we recorded postchallenge forced expiratory volume in 1 sec (FEV1) in the asthmatic group; we then performed the same measurements in 8 asthmatic and 8 normal subjects at fixed target minute ventilation (VE) for tidal volumes of 0.2 X Forced vital capacity (FVC), 0.4 X FVC, and 0.6 X FVC by varying the target respiratory rate appropriately. Our results show that (1) increasing I/E ratio or tidal volume-frequency ratio (VT/f) at fixed VE produced small but statistically significant increases (p less than 0.05) in overall heat loss per unit volume of respired gas (RHL/VE) in both asthmatic and nonasthmatic subjects of 1-4 cal/L; (2) changes in breathing pattern alone did not affect bronchoconstrictor response as assessed by lack of change in slopes and intercepts of % delta FEV1 vs. RHL dose-response curves; and (3) the increase in RHL per uni...Continue Reading

References

May 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·E R McFaddenJ J Wellman
Feb 1, 1978·The Journal of Clinical Investigation·R H StraussJ J Jaeger
Jan 1, 1977·Respiration; International Review of Thoracic Diseases·W Y Chen, D J Horton
Oct 1, 1986·The Journal of Clinical Investigation·J SolwayJ M Drazen
Dec 1, 1986·Journal of Applied Physiology·E P IngenitoJ M Drazen
Jul 1, 1985·Thorax·T H Lee, S D Anderson

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Citations

Jun 1, 1994·Biofeedback and Self-regulation·F CeugnietJ Gallego
Oct 9, 2003·Behavior Modification·Thomas Ritz, Walton T Roth
Feb 14, 2002·Journal of Applied Physiology·Paul C M van den BergMichael R Pinsky

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