Breathing pattern and respiratory mechanics in sevoflurane-anesthetized humans

Journal of Anesthesia
Y IzumiT Mizuguchi

Abstract

In order to determine the respiratory effects of sevoflurane in humans, breathing pattern and mechanical behavior of respiratory system were investigated in ten subjects at anesthetic depth of 1 MAC (minimum alveolar concentration). Average tidal volume and breathing frequency amounted to 275 ml and 20.9 breaths per minute. Arterial carbon dioxide tension amounted to 45.6 mmHg. Duration of inspiration was 1.06s and that of expiration was 1.92s. Mean inspiratory flow rate amounted to 259 ml.s(-1). Average value of passive respiratory elastance determined by the method of Zin et al. amounted to 21.8 cmH(2)O. l(-1), while those of active respiratory elastance and resistance obtained by the method of Behrakis et al. were 28.0 cmH(2)O. l(-1) and 3.15 cmH(2)O. l(-1).s(-1), respectively. Values of these variables were compared to those reported in halothane and enflurane anesthesia and possible explanations of the differences between the anesthetics are discussed.

References

Aug 1, 1987·Journal of Applied Physiology·H GautierD Zaoui
Mar 1, 1987·Anesthesia and Analgesia·M Doi, K Ikeda
Jul 1, 1974·British Journal of Anaesthesia·A M HewlettJ R Heath
Jan 1, 1973·Journal of Applied Physiology·P R WestbrookR E Hyatt
Jun 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P K BehrakisJ Milic-Emili
May 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W A ZinJ Milic-Emili
Jul 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N M SiafakasJ Milic-Emili

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Citations

Aug 1, 1995·Acta Anaesthesiologica Scandinavica·A MasudaR Takeda
Aug 11, 2012·Respiratory Physiology & Neurobiology·Vittorio AntonagliaWalter A Zin

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