Breathing reserve at the lactate threshold to differentiate a pulmonary mechanical from cardiovascular limit to exercise

Chest
B D MedoffD M Systrom

Abstract

Criteria used to define the respective roles of pulmonary mechanics and cardiovascular disease in limiting exercise performance are usually obtained at peak exercise, but are dependent on maximal patient effort. To differentiate heart from lung disease during a less effort-dependent domain of exercise, the predictive value of the breathing reserve index (BRI=minute ventilation [VE]/maximal voluntary ventilation [MVV]) at the lactate threshold (LT) was evaluated. Thirty-two patients with COPD and a pulmonary mechanical limit (PML) to exercise defined by classic criteria at maximum oxygen uptake (VO2max) were compared with 29 patients with a cardiovascular limit (CVL) and 12 normal control subjects. Expired gases and VE were measured breath by breath using a commercially available metabolic cart (Model 2001; MedGraphics Corp; St. Paul, Minn). Arterial blood gases, pH, and lactate were sampled each minute during exercise, and cardiac output (Q) was measured by first-pass radionuclide ventriculography (System 77; Baird Corp; Bedford, Mass) at rest and peak exercise. For all patients, the BRI at lactate threshold (BRILT) correlated with the BRI at VO2max (BRIMAX) (r=0.85, p<0.0001). The BRILT was higher for PML (0.73+/-0.03, mean+/-...Continue Reading

References

Jan 1, 1979·Respiration; International Review of Thoracic Diseases·M H LavietesL B Reichman
Jan 1, 1977·Medicine and Science in Sports·D A CunninghamS P Sangal
Sep 1, 1992·Medicine and Science in Sports and Exercise·T G Babb, J R Rodarte
Jan 1, 1991·Journal of Applied Physiology·T G BabbJ R Rodarte
May 1, 1990·Journal of Applied Physiology·D M SystromH Kazemi
Jan 11, 1985·The American Journal of Cardiology·K T Weber, J S Janicki
Dec 1, 1985·Journal of Applied Physiology·W L BeaverB J Whipp
Jan 1, 1973·Journal of Applied Physiology·W L BeaverB J Whipp
May 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·G Grimby, J Stiksa
Mar 1, 1969·The Journal of Clinical Investigation·S Olafsson, R E Hyatt
Jul 1, 1966·Journal of Applied Physiology·G R Kelman
Feb 1, 1984·The American Review of Respiratory Disease·J E HansenK Wasserman
Sep 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D G StubbingN L Jones
Jan 1, 1981·Medicine and Science in Sports and Exercise·D A MahlerJ Loke
Aug 1, 1994·Journal of Applied Physiology·D D MarciniukC G Gallagher
Feb 1, 1996·The European Respiratory Journal·C H HamnegårdJ Moxham

❮ Previous
Next ❯

Citations

Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Kelan G TantisiraLeo C Ginns
Jun 3, 2014·BMC Pulmonary Medicine·Jean PastréBenoit Wallaert
Jan 24, 2004·Pediatric Research·Cédric NourryPatrick Mucci
Jul 8, 2005·Thoracic Surgery Clinics·Euan A Ashley, Randall H Vagelos
Nov 1, 2012·The Journal of Pediatrics·Suchita JoshiSailesh Kotecha
Oct 14, 2016·Pediatric Pulmonology·Solon KarapanagiotisCarla Colombo
Mar 5, 2018·Journal of the American Heart Association·Mazen S AlbaghdadiAaron Baggish
Mar 13, 2013·Circulation·Bradley A MaronDavid M Systrom
Nov 5, 2008·Circulation·James J TolleDavid M Systrom
Apr 30, 2016·The European Respiratory Journal·Rudolf K F OliveiraDavid M Systrom
May 6, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Alexander R OpotowskyJonathan Rhodes
Jun 29, 2021·Current Treatment Options in Cardiovascular Medicine·J Emanuel FinetW H Wilson Tang
Nov 30, 2021·Pneumologie·Ralf EwertChristian F Opitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.