Breed differences in the pharmacokinetics of ivermectin administered subcutaneously to Holstein and Belgian Blue calves

Veterinary Parasitology
Jozef VercruysseM Alvinerie

Abstract

Belgian Blue (BB) cattle are very sensitive to mange caused by Psoroptes ovis and, in contrast to the case in Holstein cattle, single treatments with ivermectin do not result in complete elimination of the parasite. The objective of the present study was to determine the concentration of ivermectin in plasma, skin and hair following subcutaneous administration to Holstein and BB calves and to assess the influence of breed on drug pharmacokinetics and availability. Two groups of six healthy female Holstein and BB calves were treated with ivermectin (SC formulation) at a dose of 0.2 mg/kg. Blood, skin and hair were collected before treatment and up to 21 days after treatment. Ivermectin was analyzed in plasma and tissue by high-performance liquid chromatography (HPLC). The peak concentrations (Cmax), time-peak concentrations (Tmax), the area under the plasma concentration-time curves (AUC) and the mean residence time (MRT) were determined. The patterns of plasma and tissue ivermectin concentrations were similar in the two breeds of animals, however, the AUC and Cmax levels for plasma and skin were significantly higher in the BB calves. In hair, ivermectin was detected later than in plasma and skin, with the Tmax ranging between 4...Continue Reading

References

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Citations

Sep 21, 2013·Expert Opinion on Drug Metabolism & Toxicology·Anne Lespine
May 22, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gökhan EraslanSule Altinordulu
Sep 30, 2008·Veterinary Parasitology·Claudio GenchiCarlo A Sgoifo Rossi
Apr 10, 2020·Journal of Veterinary Pharmacology and Therapeutics·André Tadeu GotardoSilvana Lima Górniak
Mar 15, 2020·Parasites & Vectors·Wouter van MolEdwin Claerebout
Jan 25, 2011·The Veterinary Record·M LekimmeB Losson
Mar 20, 2012·The Veterinary Record·E S MitchellJ Williams
Oct 27, 2020·Journal of Veterinary Pharmacology and Therapeutics·Alla VyniarskaJerzy J Jaroszewski
Jun 15, 2021·Journal of the American Veterinary Medical Association·Marcy J SouzaSherry K Cox

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